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Research Article

Increased Synaptophysin Is Involved in Inflammation-Induced Heat Hyperalgesia Mediated by Cyclin-Dependent Kinase 5 in Rats

  • Hong-Hai Zhang equal contributor,

    equal contributor Contributed equally to this work with: Hong-Hai Zhang, Xiao-Qin Zhang

    Affiliation: Department of Anesthesiology Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, P.R. China

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  • Xiao-Qin Zhang equal contributor,

    equal contributor Contributed equally to this work with: Hong-Hai Zhang, Xiao-Qin Zhang

    Affiliation: Department of Anesthesiology Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, P.R. China

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  • Wen-Yuan Wang,

    Affiliation: Department of Anesthesiology Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, P.R. China

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  • Qing-Sheng Xue,

    Affiliation: Department of Anesthesiology Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, P.R. China

    X
  • Han Lu,

    Affiliation: Department of Anesthesiology Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, P.R. China

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  • Jin-Lu Huang,

    Affiliation: Department of Pharmacy, the Sixth Affiliated Hospital of Shanghai JiaoTong University School of Medicine, Shanghai, P.R. China

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  • Ting Gui,

    Affiliation: Department of Anatomy, Institutes of Medical Sciences, Shanghai JiaoTong University School of Medicine, Shanghai, P.R. China

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  • Bu-Wei Yu mail

    yubuwei_ruijin@163.com

    Affiliation: Department of Anesthesiology Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, P.R. China

    X
  • Published: October 02, 2012
  • DOI: 10.1371/journal.pone.0046666

About the Authors

Hong-Hai Zhang, Xiao-Qin Zhang, Wen-Yuan Wang, Qing-Sheng Xue, Han Lu, Bu-Wei Yu
Department of Anesthesiology Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, P.R. China
Jin-Lu Huang
Department of Pharmacy, the Sixth Affiliated Hospital of Shanghai JiaoTong University School of Medicine, Shanghai, P.R. China
Ting Gui
Department of Anatomy, Institutes of Medical Sciences, Shanghai JiaoTong University School of Medicine, Shanghai, P.R. China

Corresponding Author

Email: yubuwei_ruijin@163.com

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BWY HHZ XQZ. Performed the experiments: BWY HHZ XQZ WYW QSX HL JLH TG. Analyzed the data: HHZ XQZ WYW HL JLH. Contributed reagents/materials/analysis tools: HHZ XQZ WYW HL JLH. Wrote the paper: HHZ BWY.