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Research Article

The Mitochondrial Na+/Ca2+ Exchanger Upregulates Glucose Dependent Ca2+ Signalling Linked to Insulin Secretion

  • Iulia I. Nita,

    Affiliation: Department of Physiology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

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  • Michal Hershfinkel,

    Affiliation: Department of Morphology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

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  • Daniel Fishman,

    Affiliation: Department of Morphology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

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  • Eyal Ozeri,

    Affiliation: Department of Clinical Biochemistry, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

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  • Guy A. Rutter,

    Affiliation: Section of Cell Biology, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, Imperial College London, London, United Kingdom

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  • Stefano L. Sensi,

    Affiliations: Department of Neuroscience and Imaging, University G. d'Annunzio, Chieti-Pescara, Italy, Molecular Neurology Unit, Center of Excellence on Aging, University G. d'Annunzio, Chieti-Pescara, Italy

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  • Daniel Khananshvili,

    Affiliation: Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Ramat-Aviv, Israel

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  • Eli C. Lewis,

    Affiliation: Department of Clinical Biochemistry, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

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  • Israel Sekler mail

    sekler@bgu.ac.il

    Affiliation: Department of Physiology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

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  • Published: October 08, 2012
  • DOI: 10.1371/journal.pone.0046649

About the Authors

Iulia I. Nita, Israel Sekler
Department of Physiology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Michal Hershfinkel, Daniel Fishman
Department of Morphology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Eyal Ozeri, Eli C. Lewis
Department of Clinical Biochemistry, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Guy A. Rutter
Section of Cell Biology, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, Imperial College London, London, United Kingdom
Stefano L. Sensi
Department of Neuroscience and Imaging, University G. d'Annunzio, Chieti-Pescara, Italy
Stefano L. Sensi
Molecular Neurology Unit, Center of Excellence on Aging, University G. d'Annunzio, Chieti-Pescara, Italy
Daniel Khananshvili
Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Ramat-Aviv, Israel

Corresponding Author

Email: sekler@bgu.ac.il

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: IN IS MH EL. Performed the experiments: IN DF. Analyzed the data: IN MH GR DK IS. Contributed reagents/materials/analysis tools: EL EO DF. Wrote the paper: IN IS MH GR DK SLS.