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Research Article

mNanog Possesses Dorsal Mesoderm-Inducing Ability by Modulating Both BMP and Activin/Nodal Signaling in Xenopus Ectodermal Cells

  • Aya Miyazaki equal contributor,

    equal contributor Contributed equally to this work with: Aya Miyazaki, Kentaro Ishii

    Affiliation: Department of Life Sciences (Biology), Graduate School of Arts and Sciences, the University of Tokyo, Tokyo, Japan

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  • Kentaro Ishii equal contributor,

    equal contributor Contributed equally to this work with: Aya Miyazaki, Kentaro Ishii

    Affiliation: Department of Life Sciences (Biology), Graduate School of Arts and Sciences, the University of Tokyo, Tokyo, Japan

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  • Satoshi Yamashita,

    Affiliation: Department of Life Sciences (Biology), Graduate School of Arts and Sciences, the University of Tokyo, Tokyo, Japan

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  • Susumu Nejigane,

    Affiliation: Department of Life Sciences (Biology), Graduate School of Arts and Sciences, the University of Tokyo, Tokyo, Japan

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  • Shinya Matsukawa,

    Affiliation: Department of Life Sciences (Biology), Graduate School of Arts and Sciences, the University of Tokyo, Tokyo, Japan

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  • Yuzuru Ito,

    Affiliation: Research Center for Stem Cell Engineering, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba City, Ibaraki, Japan

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  • Yasuko Onuma,

    Affiliation: Research Center for Stem Cell Engineering, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba City, Ibaraki, Japan

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  • Makoto Asashima,

    Affiliations: Department of Life Sciences (Biology), Graduate School of Arts and Sciences, the University of Tokyo, Tokyo, Japan, Research Center for Stem Cell Engineering, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba City, Ibaraki, Japan

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  • Tatsuo Michiue mail

    tmichiue@bio.c.u-tokyo.ac.jp

    Affiliation: Department of Life Sciences (Biology), Graduate School of Arts and Sciences, the University of Tokyo, Tokyo, Japan

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  • Published: October 11, 2012
  • DOI: 10.1371/journal.pone.0046630

About the Authors

Aya Miyazaki, Kentaro Ishii, Satoshi Yamashita, Susumu Nejigane, Shinya Matsukawa, Makoto Asashima, Tatsuo Michiue
Department of Life Sciences (Biology), Graduate School of Arts and Sciences, the University of Tokyo, Tokyo, Japan
Yuzuru Ito, Yasuko Onuma, Makoto Asashima
Research Center for Stem Cell Engineering, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba City, Ibaraki, Japan

Corresponding Author

Email: tmichiue@bio.c.u-tokyo.ac.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TM. Performed the experiments: TM AM KI SY SN SM. Analyzed the data: TM AM YI YO SM. Contributed reagents/materials/analysis tools: TM YI YO MA SM. Wrote the paper: TM AM.