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Research Article

Cell Stiffness Is a Biomarker of the Metastatic Potential of Ovarian Cancer Cells

  • Wenwei Xu equal contributor,

    equal contributor Contributed equally to this work with: Wenwei Xu, Roman Mezencev

    Affiliation: The George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia, United States of America

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  • Roman Mezencev equal contributor,

    equal contributor Contributed equally to this work with: Wenwei Xu, Roman Mezencev

    Affiliation: School of Biology, Georgia Institute of Technology, Atlanta, Georgia, United States of America

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  • Byungkyu Kim,

    Affiliation: The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, United States of America

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  • Lijuan Wang,

    Affiliation: School of Biology, Georgia Institute of Technology, Atlanta, Georgia, United States of America

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  • John McDonald,

    Affiliation: School of Biology, Georgia Institute of Technology, Atlanta, Georgia, United States of America

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  • Todd Sulchek mail

    todd.sulchek@me.gatech.edu

    Affiliations: The George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia, United States of America, School of Biology, Georgia Institute of Technology, Atlanta, Georgia, United States of America, The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, United States of America

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  • Published: October 04, 2012
  • DOI: 10.1371/journal.pone.0046609

About the Authors

Wenwei Xu, Todd Sulchek
The George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia, United States of America
Roman Mezencev, Lijuan Wang, John McDonald, Todd Sulchek
School of Biology, Georgia Institute of Technology, Atlanta, Georgia, United States of America
Byungkyu Kim, Todd Sulchek
The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, United States of America

Corresponding Author

Email: todd.sulchek@me.gatech.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WX RM JM TS. Performed the experiments: WX RM BK LW TS. Analyzed the data: WX RM BK LW JM TS. Contributed reagents/materials/analysis tools: WX RM BK LW JM TS. Wrote the paper: WX RM JM TS.