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Research Article

Neurovirulence of H5N1 Infection in Ferrets Is Mediated by Multifocal Replication in Distinct Permissive Neuronal Cell Regions

  • Jennifer R. Plourde,

    Affiliations: Infectious Diseases Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico, United States of America, Department of Pathology, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States of America

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  • John A. Pyles,

    Affiliation: Infectious Diseases Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico, United States of America

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  • R. Colby Layton,

    Affiliation: Infectious Diseases Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico, United States of America

    Current address: Virology and Infectious Disease Animal Models, MRIGlobal, Kansas City, Missouri, United States of America

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  • Sarah E. Vaughan,

    Affiliations: Infectious Diseases Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico, United States of America, Department of Pathology, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States of America

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  • Jennifer L. Tipper,

    Affiliation: Infectious Diseases Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico, United States of America

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  • Kevin S. Harrod mail

    kharrod@lrri.org

    Affiliations: Infectious Diseases Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico, United States of America, Department of Pathology, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States of America

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  • Published: October 08, 2012
  • DOI: 10.1371/journal.pone.0046605

About the Authors

Jennifer R. Plourde, John A. Pyles, R. Colby Layton, Sarah E. Vaughan, Jennifer L. Tipper, Kevin S. Harrod
Infectious Diseases Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico, United States of America
Jennifer R. Plourde, Sarah E. Vaughan, Kevin S. Harrod
Department of Pathology, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States of America

Corresponding Author

Email: kharrod@lrri.org

Competing Interests

The authors have read the journal's policy and have the following conflicts: The corresponding author, Kevin Harrod, is a PLOS ONE Editorial Board member. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JRP RCL JLT KSH. Performed the experiments: JRP JAP RCL SEV. Analyzed the data: JRP KSH. Contributed reagents/materials/analysis tools: JRP JLT KSH. Wrote the paper: JRP KSH.