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Research Article

The Primacy of β1 Integrin Activation in the Metastatic Cascade

  • Hisashi Kato,

    Affiliation: Department of Medicine, University of California San Diego, La Jolla, California, United States of America

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  • Zhongji Liao,

    Affiliation: Department of Medicine, University of California San Diego, La Jolla, California, United States of America

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  • John V. Mitsios,

    Affiliation: Department of Medicine, University of California San Diego, La Jolla, California, United States of America

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  • Huan-You Wang,

    Affiliations: Moores UCSD Cancer Center, University of California San Diego, La Jolla, California, United States of America, Department of Pathology, Moores UCSD Cancer Center, University of California San Diego, La Jolla, California, United States of America

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  • Elena I. Deryugina,

    Affiliation: Department of Cell Biology, The Scripps Research Institute, La Jolla, California, United States of America

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  • Judith A. Varner,

    Affiliations: Department of Medicine, University of California San Diego, La Jolla, California, United States of America, Moores UCSD Cancer Center, University of California San Diego, La Jolla, California, United States of America

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  • James P. Quigley,

    Affiliation: Department of Cell Biology, The Scripps Research Institute, La Jolla, California, United States of America

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  • Sanford J. Shattil mail

    sshattil@ucsd.edu

    Affiliations: Department of Medicine, University of California San Diego, La Jolla, California, United States of America, Moores UCSD Cancer Center, University of California San Diego, La Jolla, California, United States of America

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  • Published: October 03, 2012
  • DOI: 10.1371/journal.pone.0046576

About the Authors

Hisashi Kato, Zhongji Liao, John V. Mitsios, Judith A. Varner, Sanford J. Shattil
Department of Medicine, University of California San Diego, La Jolla, California, United States of America
Huan-You Wang, Judith A. Varner, Sanford J. Shattil
Moores UCSD Cancer Center, University of California San Diego, La Jolla, California, United States of America
Huan-You Wang
Department of Pathology, Moores UCSD Cancer Center, University of California San Diego, La Jolla, California, United States of America
Elena I. Deryugina, James P. Quigley
Department of Cell Biology, The Scripps Research Institute, La Jolla, California, United States of America

Corresponding Author

Email: sshattil@ucsd.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HK EID JPQ SJS. Performed the experiments: HK ZL JVM. Analyzed the data: HK ZL H-YW EID JAV JPQ SJS. Contributed reagents/materials/analysis tools: JAV. Wrote the paper: HK EID JAV JPQ SJS.