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Research Article

Gene Expression in Uninvolved Oral Mucosa of OSCC Patients Facilitates Identification of Markers Predictive of OSCC Outcomes

  • Pawadee Lohavanichbutr,

    Affiliation: Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • John Houck,

    Affiliation: Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • David R. Doody,

    Affiliation: Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • Pei Wang,

    Affiliation: Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • Eduardo Mendez,

    Affiliations: Department of Otolaryngology – Head and Neck Surgery, University of Washington, Seattle, Washington, United States of America, Surgery and Perioperative Care Service, VA Puget Sound Health Care System, Seattle, Washington, United States of America, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • Neal Futran,

    Affiliation: Department of Otolaryngology – Head and Neck Surgery, University of Washington, Seattle, Washington, United States of America

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  • Melissa P. Upton,

    Affiliation: Department of Pathology, University of Washington, Seattle, Washington, United States of America

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  • F. Christopher Holsinger,

    Affiliation: Department of Otolaryngology – Head and Neck Surgery, MD Anderson Cancer Center, Houston, Texas, United States of America

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  • Stephen M. Schwartz,

    Affiliations: Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America

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  • Chu Chen mail

    cchen@fhcrc.org

    Affiliations: Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Otolaryngology – Head and Neck Surgery, University of Washington, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America

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  • Published: September 28, 2012
  • DOI: 10.1371/journal.pone.0046575

About the Authors

Pawadee Lohavanichbutr, John Houck, David R. Doody, Stephen M. Schwartz, Chu Chen
Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
Pei Wang
Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
Eduardo Mendez, Neal Futran, Chu Chen
Department of Otolaryngology – Head and Neck Surgery, University of Washington, Seattle, Washington, United States of America
Eduardo Mendez
Surgery and Perioperative Care Service, VA Puget Sound Health Care System, Seattle, Washington, United States of America
Eduardo Mendez
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
Melissa P. Upton
Department of Pathology, University of Washington, Seattle, Washington, United States of America
F. Christopher Holsinger
Department of Otolaryngology – Head and Neck Surgery, MD Anderson Cancer Center, Houston, Texas, United States of America
Stephen M. Schwartz, Chu Chen
Department of Epidemiology, University of Washington, Seattle, Washington, United States of America

Corresponding Author

Email: cchen@fhcrc.org

Competing Interests

Dr. Neal Futran is a consultant with the Stryker conmpany, though it has no bearing on this manuscript; and Dr. Eduardo Mendez has a consulting/honorarium agreement with Intuitive Surgical, Inc. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: CC PL SS PW. Performed the experiments: PL JH. Analyzed the data: DD PL PW. Contributed reagents/materials/analysis tools: EM NF MU FCH. Wrote the paper: PL.