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Research Article

Human Surfactant Protein A2 Gene Mutations Impair Dimmer/Trimer Assembly Leading to Deficiency in Protein Sialylation and Secretion

  • Yi Song equal contributor,

    equal contributor Contributed equally to this work with: Yi Song, Guodong Fang

    Affiliation: Department of Pathology, Shantou University Medical College, Shantou, Guangdong, People’s Republic of China

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  • Guodong Fang equal contributor,

    equal contributor Contributed equally to this work with: Yi Song, Guodong Fang

    Affiliation: Department of Pathology, Shantou University Medical College, Shantou, Guangdong, People’s Republic of China

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  • Haitao Shen,

    Affiliation: Department of Pathology, Shantou University Medical College, Shantou, Guangdong, People’s Republic of China

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  • Hui Li,

    Affiliation: Department of Pathology, Shantou University Medical College, Shantou, Guangdong, People’s Republic of China

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  • Wenbing Yang,

    Affiliation: Department of Pathology, Shantou University Medical College, Shantou, Guangdong, People’s Republic of China

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  • Bing Pan,

    Affiliation: The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Sciences of Education Ministry, and Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides of Health Ministry, Beijing, People’s Republic of China

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  • Guowei Huang,

    Affiliation: Department of Pathology, Shantou University Medical College, Shantou, Guangdong, People’s Republic of China

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  • Guangyu Lin,

    Affiliations: Department of Pediatrics, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, People’s Republic of China, Translational Medicine Center, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, People’s Republic of China

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  • Lian Ma,

    Affiliations: Department of Pediatrics, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, People’s Republic of China, Translational Medicine Center, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, People’s Republic of China

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  • Belinda Willard,

    Affiliation: Proteomics Laboratory, Cleveland Clinic, Cleveland, Ohio, United States of America

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  • Jiang Gu,

    Affiliation: Department of Pathology, Shantou University Medical College, Shantou, Guangdong, People’s Republic of China

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  • Lemin Zheng mail,

    yywangut@gmail.com (YW); zhengl@bjmu.edu.cn (LZ)

    Affiliation: The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Sciences of Education Ministry, and Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides of Health Ministry, Beijing, People’s Republic of China

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  • Yongyu Wang mail

    yywangut@gmail.com (YW); zhengl@bjmu.edu.cn (LZ)

    Affiliation: Department of Pathology, Shantou University Medical College, Shantou, Guangdong, People’s Republic of China

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  • Published: October 03, 2012
  • DOI: 10.1371/journal.pone.0046559

About the Authors

Yi Song, Guodong Fang, Haitao Shen, Hui Li, Wenbing Yang, Guowei Huang, Jiang Gu, Yongyu Wang
Department of Pathology, Shantou University Medical College, Shantou, Guangdong, People’s Republic of China
Guangyu Lin, Lian Ma
Department of Pediatrics, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, People’s Republic of China
Guangyu Lin, Lian Ma
Translational Medicine Center, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, People’s Republic of China
Bing Pan, Lemin Zheng
The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Sciences of Education Ministry, and Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides of Health Ministry, Beijing, People’s Republic of China
Belinda Willard
Proteomics Laboratory, Cleveland Clinic, Cleveland, Ohio, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YW YS GF LZ. Performed the experiments: YS GF HS HL WY GH YW. Analyzed the data: YS GF LZ YW. Contributed reagents/materials/analysis tools: BP GL LM JG. Wrote the paper: YW LZ BW.