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Research Article

Recombinant Human MFG-E8 Attenuates Intestinal Injury and Mortality in Severe Whole Body Irradiation in Rats

  • Michael A. Ajakaiye,

    Affiliation: Center for Immunology and Inflammation, The Feinstein Institute for Medical Research, and Department of Surgery, Hofstra North Shore-LIJ School of Medicine, Manhasset, New York, United States of America

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  • Asha Jacob,

    Affiliation: Center for Immunology and Inflammation, The Feinstein Institute for Medical Research, and Department of Surgery, Hofstra North Shore-LIJ School of Medicine, Manhasset, New York, United States of America

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  • Rongqian Wu,

    Affiliation: Center for Immunology and Inflammation, The Feinstein Institute for Medical Research, and Department of Surgery, Hofstra North Shore-LIJ School of Medicine, Manhasset, New York, United States of America

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  • Weng Lang Yang,

    Affiliation: Center for Immunology and Inflammation, The Feinstein Institute for Medical Research, and Department of Surgery, Hofstra North Shore-LIJ School of Medicine, Manhasset, New York, United States of America

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  • Jeffrey Nicastro,

    Affiliation: Center for Immunology and Inflammation, The Feinstein Institute for Medical Research, and Department of Surgery, Hofstra North Shore-LIJ School of Medicine, Manhasset, New York, United States of America

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  • Gene F. Coppa,

    Affiliation: Center for Immunology and Inflammation, The Feinstein Institute for Medical Research, and Department of Surgery, Hofstra North Shore-LIJ School of Medicine, Manhasset, New York, United States of America

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  • Ping Wang mail

    pwang@nshs.edu

    Affiliation: Center for Immunology and Inflammation, The Feinstein Institute for Medical Research, and Department of Surgery, Hofstra North Shore-LIJ School of Medicine, Manhasset, New York, United States of America

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  • Published: October 08, 2012
  • DOI: 10.1371/journal.pone.0046540

About the Authors

Michael A. Ajakaiye, Asha Jacob, Rongqian Wu, Weng Lang Yang, Jeffrey Nicastro, Gene F. Coppa, Ping Wang
Center for Immunology and Inflammation, The Feinstein Institute for Medical Research, and Department of Surgery, Hofstra North Shore-LIJ School of Medicine, Manhasset, New York, United States of America

Corresponding Author

Email: pwang@nshs.edu

Competing Interests

One of the authors (P. Wang) is an inventor of the pending PCT application #WO/2006/122327: “Milk fat globule epidermal growth factor-factor VIII and sepsis”? and PCT application #WO/2009/064448: “Prevention and treatment of inflammation and organ injury after ischemia/reperfusion using MFG-E8.”? These patent applications cover the fundamental concept of using MFG-E8 for the treatment of sepsis and ischemia/reperfusion injury. Other authors have declared that no competing interests exist. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: RW PW. Performed the experiments: MA WLY. Analyzed the data: MA AJ RW WLY. Contributed reagents/materials/analysis tools: PW. Wrote the paper: MA AJ RW JN GC PW.