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Research Article

Rare and Low Frequency Variant Stratification in the UK Population: Description and Impact on Association Tests

  • Marie-Claude Babron,

    Affiliations: Inserm UMRS-946, Genetic variability and human diseases, Paris, France, Institut Universitaire d'Hématologie, Univ Paris Diderot, Paris, France

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  • Marie de Tayrac,

    Affiliations: Inserm UMRS-946, Genetic variability and human diseases, Paris, France, Institut Universitaire d'Hématologie, Univ Paris Diderot, Paris, France

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  • Douglas N. Rutledge,

    Affiliation: AgroParisTech, Paris, France

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  • Eleftheria Zeggini equal contributor,

    equal contributor Contributed equally to this work with: Eleftheria Zeggini, Emmanuelle Génin

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

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  • Emmanuelle Génin equal contributor mail

    equal contributor Contributed equally to this work with: Eleftheria Zeggini, Emmanuelle Génin

    emmanuelle.genin@inserm.fr

    Affiliations: Inserm UMRS-946, Genetic variability and human diseases, Paris, France, Institut Universitaire d'Hématologie, Univ Paris Diderot, Paris, France

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  • Published: October 05, 2012
  • DOI: 10.1371/journal.pone.0046519

About the Authors

Marie-Claude Babron, Marie de Tayrac, Emmanuelle Génin
Inserm UMRS-946, Genetic variability and human diseases, Paris, France
Marie-Claude Babron, Marie de Tayrac, Emmanuelle Génin
Institut Universitaire d'Hématologie, Univ Paris Diderot, Paris, France
Douglas N. Rutledge
AgroParisTech, Paris, France
Eleftheria Zeggini
Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

Corresponding Author

Email: emmanuelle.genin@inserm.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EG EZ. Performed the experiments: MCB MDT DR. Analyzed the data: EG EZ MCB DR MDT. Wrote the paper: EG EZ MCB.