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Research Article

Acute Reactogenicity after Intramuscular Immunization with Recombinant Vesicular Stomatitis Virus Is Linked to Production of IL-1β

  • Kathleen Athearn,

    Affiliations: Human Vaccine Institute, School of Medicine, Duke University, Durham, North Carolina, United States of America, Department of Medicine, School of Medicine, Duke University, Durham, North Carolina, United States of America, Department of Pathology, School of Medicine, Duke University, Durham, North Carolina, United States of America

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  • Christopher J. Sample,

    Affiliations: Human Vaccine Institute, School of Medicine, Duke University, Durham, North Carolina, United States of America, Department of Medicine, School of Medicine, Duke University, Durham, North Carolina, United States of America

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  • Brice E. Barefoot,

    Affiliations: Human Vaccine Institute, School of Medicine, Duke University, Durham, North Carolina, United States of America, Department of Medicine, School of Medicine, Duke University, Durham, North Carolina, United States of America

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  • Kristi L. Williams equal contributor,

    equal contributor Contributed equally to this work with: Kristi L. Williams, Elizabeth A. Ramsburg

    Affiliations: Department of Medicine, School of Medicine, Duke University, Durham, North Carolina, United States of America, School of Nursing, School of Medicine, Duke University, Durham, North Carolina, United States of America

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  • Elizabeth A. Ramsburg equal contributor mail

    equal contributor Contributed equally to this work with: Kristi L. Williams, Elizabeth A. Ramsburg

    elizabeth.ramsburg@dm.duke.edu

    Affiliations: Human Vaccine Institute, School of Medicine, Duke University, Durham, North Carolina, United States of America, Department of Medicine, School of Medicine, Duke University, Durham, North Carolina, United States of America, Department of Pathology, School of Medicine, Duke University, Durham, North Carolina, United States of America

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  • Published: October 08, 2012
  • DOI: 10.1371/journal.pone.0046516

About the Authors

Kathleen Athearn, Christopher J. Sample, Brice E. Barefoot, Elizabeth A. Ramsburg
Human Vaccine Institute, School of Medicine, Duke University, Durham, North Carolina, United States of America
Kathleen Athearn, Christopher J. Sample, Brice E. Barefoot, Kristi L. Williams, Elizabeth A. Ramsburg
Department of Medicine, School of Medicine, Duke University, Durham, North Carolina, United States of America
Kathleen Athearn, Elizabeth A. Ramsburg
Department of Pathology, School of Medicine, Duke University, Durham, North Carolina, United States of America
Kristi L. Williams
School of Nursing, School of Medicine, Duke University, Durham, North Carolina, United States of America

Corresponding Author

Email: elizabeth.ramsburg@dm.duke.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ER KA KW. Performed the experiments: KA CS BB. Analyzed the data: KA CS BB ER. Contributed reagents/materials/analysis tools: KW. Wrote the paper: ER.