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Research Article

Neutralisation of Peritoneal IL-17A Markedly Improves the Prognosis of Severe Septic Mice by Decreasing Neutrophil Infiltration and Proinflammatory Cytokines

  • Jinbao Li equal contributor,

    equal contributor Contributed equally to this work with: Jinbao Li, Yan Zhang, Jingsheng Lou

    Affiliation: Department of Anesthesiology, Changhai Hospital, and Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai, China

    X
  • Yan Zhang equal contributor,

    equal contributor Contributed equally to this work with: Jinbao Li, Yan Zhang, Jingsheng Lou

    Affiliation: Department of Anesthesiology, Changhai Hospital, and Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai, China

    X
  • Jingsheng Lou equal contributor,

    equal contributor Contributed equally to this work with: Jinbao Li, Yan Zhang, Jingsheng Lou

    Affiliations: Department of Anesthesiology, Changhai Hospital, and Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai, China, Department of Anesthesiology, General Hospital of PLA, Beijing, China

    X
  • Jiali Zhu,

    Affiliation: Department of Anesthesiology, Changhai Hospital, and Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai, China

    X
  • Miaoxia He,

    Affiliation: Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai, China

    X
  • Xiaoming Deng mail,

    deng_x@yahoo.com (XD); czl8003@163.com (ZC)

    Affiliation: Department of Anesthesiology, Changhai Hospital, and Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai, China

    X
  • Zailong Cai mail

    deng_x@yahoo.com (XD); czl8003@163.com (ZC)

    Affiliation: Department of Anesthesiology, Changhai Hospital, and Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai, China

    X
  • Published: October 02, 2012
  • DOI: 10.1371/journal.pone.0046506

About the Authors

Jinbao Li, Yan Zhang, Jingsheng Lou, Jiali Zhu, Xiaoming Deng, Zailong Cai
Department of Anesthesiology, Changhai Hospital, and Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai, China
Miaoxia He
Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai, China
Jingsheng Lou
Department of Anesthesiology, General Hospital of PLA, Beijing, China

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JBL XMD ZLC. Performed the experiments: YZ JSL. Analyzed the data: JSL MXH. Contributed reagents/materials/analysis tools: JLZ. Wrote the paper: JSL ZLC.