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Research Article

Reproducibility, Performance, and Clinical Utility of a Genetic Risk Prediction Model for Prostate Cancer in Japanese

  • Shusuke Akamatsu,

    Affiliations: Laboratory for Biomarker Development, Center for Genomic Medicine, RIKEN, Tokyo, Japan, Department of Urology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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  • Atsushi Takahashi,

    Affiliation: Laboratory for Statistical Analysis, Center for Genomic Medicine, RIKEN, Tokyo, Japan

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  • Ryo Takata,

    Affiliations: Laboratory for Biomarker Development, Center for Genomic Medicine, RIKEN, Tokyo, Japan, Department of Urology, Iwate Medical University, Morioka, Japan

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  • Michiaki Kubo,

    Affiliation: Laboratory for Genotyping Development, Center for Genomic Medicine, RIKEN, Yokohama, Japan

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  • Takahiro Inoue,

    Affiliation: Department of Urology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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  • Takashi Morizono,

    Affiliation: Laboratory for Medical Informatics, Center for Genomic Medicine, RIKEN, Yokohama, Japan

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  • Tatsuhiko Tsunoda,

    Affiliation: Laboratory for Medical Informatics, Center for Genomic Medicine, RIKEN, Yokohama, Japan

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  • Naoyuki Kamatani,

    Affiliation: Laboratory for Statistical Analysis, Center for Genomic Medicine, RIKEN, Tokyo, Japan

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  • Christopher A. Haiman,

    Affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Peggy Wan,

    Affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Gary K. Chen,

    Affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Loic Le Marchand,

    Affiliation: Epidemiology Program, Cancer Research Centre, University of Hawaii, Honolulu, Hawaii, United States of America

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  • Laurence N. Kolonel,

    Affiliation: Epidemiology Program, Cancer Research Centre, University of Hawaii, Honolulu, Hawaii, United States of America

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  • Brian E. Henderson,

    Affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Tomoaki Fujioka,

    Affiliation: Laboratory for Statistical Analysis, Center for Genomic Medicine, RIKEN, Tokyo, Japan

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  • Tomonori Habuchi,

    Affiliation: Department of Urology, Akita University School of Medicine, Akita, Japan

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  • Yusuke Nakamura,

    Affiliation: Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, the University of Tokyo, Tokyo, Japan

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  • Osamu Ogawa,

    Affiliation: Department of Urology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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  • Hidewaki Nakagawa mail

    hidewaki@ims.u-tokyo.ac.jp

    Affiliation: Laboratory for Biomarker Development, Center for Genomic Medicine, RIKEN, Tokyo, Japan

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  • Published: October 10, 2012
  • DOI: 10.1371/journal.pone.0046454

About the Authors

Shusuke Akamatsu, Ryo Takata, Hidewaki Nakagawa
Laboratory for Biomarker Development, Center for Genomic Medicine, RIKEN, Tokyo, Japan
Shusuke Akamatsu, Takahiro Inoue, Osamu Ogawa
Department of Urology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Atsushi Takahashi, Naoyuki Kamatani, Tomoaki Fujioka
Laboratory for Statistical Analysis, Center for Genomic Medicine, RIKEN, Tokyo, Japan
Ryo Takata
Department of Urology, Iwate Medical University, Morioka, Japan
Michiaki Kubo
Laboratory for Genotyping Development, Center for Genomic Medicine, RIKEN, Yokohama, Japan
Takashi Morizono, Tatsuhiko Tsunoda
Laboratory for Medical Informatics, Center for Genomic Medicine, RIKEN, Yokohama, Japan
Christopher A. Haiman, Peggy Wan, Gary K. Chen, Brian E. Henderson
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
Loic Le Marchand, Laurence N. Kolonel
Epidemiology Program, Cancer Research Centre, University of Hawaii, Honolulu, Hawaii, United States of America
Tomonori Habuchi
Department of Urology, Akita University School of Medicine, Akita, Japan
Yusuke Nakamura
Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, the University of Tokyo, Tokyo, Japan

Corresponding Author

Email: hidewaki@ims.u-tokyo.ac.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SA RT YN OO HN. Performed the experiments: SA AT TI CAH. Analyzed the data: SA AT RT TM TT NK CAH PW GKC. Contributed reagents/materials/analysis tools: TI MK TM TT NK CAH LLM LNK BEH TF TH YN OO. Wrote the paper: SA AT CAH HN.