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Research Article

Neurofibrillary Tangles and the Deposition of a Beta Amyloid Peptide with a Novel N-Terminal Epitope in the Brains of Wild Tsushima Leopard Cats

  • James K. Chambers mail,

    achamber@mail.ecc.u-tokyo.ac.jp

    Affiliation: Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, the University of Tokyo, Tokyo, Japan

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  • Kazuyuki Uchida,

    Affiliation: Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, the University of Tokyo, Tokyo, Japan

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  • Tomoyuki Harada,

    Affiliation: Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, the University of Tokyo, Tokyo, Japan

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  • Masaya Tsuboi,

    Affiliation: Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, the University of Tokyo, Tokyo, Japan

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  • Masumi Sato,

    Affiliation: National Institute of Animal Health, Ibaraki, Japan

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  • Masahito Kubo,

    Affiliation: Laboratory of Veterinary Pathology, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan

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  • Hiroaki Kawaguchi,

    Affiliation: Laboratory of Veterinary Histopathology, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan

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  • Noriaki Miyoshi,

    Affiliation: Laboratory of Veterinary Histopathology, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan

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  • Hajime Tsujimoto,

    Affiliation: Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, the University of Tokyo, Tokyo, Japan

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  • Hiroyuki Nakayama

    Affiliation: Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, the University of Tokyo, Tokyo, Japan

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  • Published: October 03, 2012
  • DOI: 10.1371/journal.pone.0046452

About the Authors

James K. Chambers, Kazuyuki Uchida, Tomoyuki Harada, Masaya Tsuboi, Hiroyuki Nakayama
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, the University of Tokyo, Tokyo, Japan
Masumi Sato
National Institute of Animal Health, Ibaraki, Japan
Masahito Kubo
Laboratory of Veterinary Pathology, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan
Hiroaki Kawaguchi, Noriaki Miyoshi
Laboratory of Veterinary Histopathology, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan
Hajime Tsujimoto
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, the University of Tokyo, Tokyo, Japan

Corresponding Author

Email: achamber@mail.ecc.u-tokyo.ac.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JKC KU HN. Performed the experiments: JKC TH MT. Analyzed the data: JKC KU HN. Contributed reagents/materials/analysis tools: MS MK HK NM HT. Wrote the paper: JKC.