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Research Article

Silencing of Glutathione Peroxidase 3 through DNA Hypermethylation Is Associated with Lymph Node Metastasis in Gastric Carcinomas

  • Dun-Fa Peng,

    Affiliation: Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Tian-Ling Hu,

    Affiliation: Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Barbara G. Schneider,

    Affiliation: Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Zheng Chen,

    Affiliations: Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China

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  • Ze-Kuan Xu,

    Affiliations: Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China, Institute of Tumor Biology, Jiangsu Province Academy of Clinical Medicine, Nanjing, China

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  • Wael El-Rifai mail

    wael.el-rifai@Vanderbilt.edu

    Affiliations: Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Department of Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee, United States of America

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  • Published: October 10, 2012
  • DOI: 10.1371/journal.pone.0046214

About the Authors

Dun-Fa Peng, Tian-Ling Hu, Zheng Chen, Wael El-Rifai
Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
Barbara G. Schneider
Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
Wael El-Rifai
Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
Wael El-Rifai
Department of Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee, United States of America
Zheng Chen, Ze-Kuan Xu
Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Ze-Kuan Xu
Institute of Tumor Biology, Jiangsu Province Academy of Clinical Medicine, Nanjing, China

Corresponding Author

Email: wael.el-rifai@Vanderbilt.edu

Competing Interests

Co-author Wael El-Rifai is a PLOS ONE Editorial Board member. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: DFP WER ZKX BS. Performed the experiments: TLH ZC DP. Analyzed the data: DFP WER. Contributed reagents/materials/analysis tools: DFP WER. Wrote the paper: DFP WER BS.