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Research Article

Khz (Fusion of Ganoderma lucidum and Polyporus umbellatus Mycelia) Induces Apoptosis by Increasing Intracellular Calcium Levels and Activating JNK and NADPH Oxidase-Dependent Generation of Reactive Oxygen Species

  • Tae Hwan Kim,

    Affiliation: Department of Radiotherapy, The First Affiliated Hospital, Guangxi Medical University, Nanning, China

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  • Ju sung Kim,

    Affiliation: Clinical Medicine, Harbin Medical University, Harbin, China

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  • Zoo haye Kim,

    Affiliation: Graduate School of Information Science, Nagoya University, Nagoya, Japan

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  • Ren Bin Huang,

    Affiliation: Graduate School of Pharmacology, Guangxi Medical University, Nanning, China

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  • Ren Sheng Wang mail

    wrsgx@yahoo.com.cn

    Affiliation: Department of Radiotherapy, The First Affiliated Hospital, Guangxi Medical University, Nanning, China

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  • Published: October 08, 2012
  • DOI: 10.1371/journal.pone.0046208

About the Authors

Tae Hwan Kim, Ren Sheng Wang
Department of Radiotherapy, The First Affiliated Hospital, Guangxi Medical University, Nanning, China
Ju sung Kim
Clinical Medicine, Harbin Medical University, Harbin, China
Zoo haye Kim
Graduate School of Information Science, Nagoya University, Nagoya, Japan
Ren Bin Huang
Graduate School of Pharmacology, Guangxi Medical University, Nanning, China

Corresponding Author

Email: wrsgx@yahoo.com.cn

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: THK JSK ZHK RBH RSW. Performed the experiments: THK JSK ZHK RBH RSW. Analyzed the data: THK JSK ZHK RBH RSW. Contributed reagents/materials/analysis tools: THK JSK ZHK RBH RSW. Wrote the paper: THK JSK ZHK RBH RSW.