About the Authors

David He

Affiliations Program in Molecular Structure and Function, Hospital for Sick Children, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

Ming Miao

Affiliation Program in Molecular Structure and Function, Hospital for Sick Children, Toronto, Ontario, Canada

Eva E. Sitarz

Affiliation Program in Molecular Structure and Function, Hospital for Sick Children, Toronto, Ontario, Canada

Lisa D. Muiznieks

Affiliation Program in Molecular Structure and Function, Hospital for Sick Children, Toronto, Ontario, Canada

Sean Reichheld

Affiliation Program in Molecular Structure and Function, Hospital for Sick Children, Toronto, Ontario, Canada

Richard J. Stahl

Affiliation Program in Molecular Structure and Function, Hospital for Sick Children, Toronto, Ontario, Canada

Fred W. Keeley

Affiliations Program in Molecular Structure and Function, Hospital for Sick Children, Toronto, Ontario, Canada, Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada

John Parkinson

jparkin@sickkids.ca

Affiliations Program in Molecular Structure and Function, Hospital for Sick Children, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada, Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada

Competing Interests

John Parkinson is a PLOS ONE Editorial Board member. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: DH FWK JP. Performed the experiments: DH MM EES LDM SR RJS. Analyzed the data: DH MM RJS FWK JP. Wrote the paper: DH FWK JP.