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Research Article

Proteome Analysis Identified the PPARγ Ligand 15d-PGJ2 as a Novel Drug Inhibiting Melanoma Progression and Interfering with Tumor-Stroma Interaction

  • Verena Paulitschke,

    Affiliation: Department of Dermatology, Medical University of Vienna, Vienna, Austria

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  • Silke Gruber,

    Affiliation: Department of Dermatology, Medical University of Vienna, Vienna, Austria

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  • Elisabeth Hofstätter,

    Affiliation: Department of Dermatology, Medical University of Vienna, Vienna, Austria

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  • Verena Haudek-Prinz,

    Affiliation: Department of Medicine I, Medical University of Vienna, Vienna, Austria

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  • Philipp Klepeisz,

    Affiliation: Department of Medicine I, Medical University of Vienna, Vienna, Austria

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  • Nikolaus Schicher,

    Affiliation: Department of Dermatology, Medical University of Vienna, Vienna, Austria

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  • Constanze Jonak,

    Affiliation: Department of Dermatology, Medical University of Vienna, Vienna, Austria

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  • Peter Petzelbauer,

    Affiliation: Department of Dermatology, Medical University of Vienna, Vienna, Austria

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  • Hubert Pehamberger,

    Affiliation: Department of Dermatology, Medical University of Vienna, Vienna, Austria

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  • Christopher Gerner,

    Affiliation: Department of Medicine I, Medical University of Vienna, Vienna, Austria

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  • Rainer Kunstfeld mail

    rainer.kunstfeld@meduniwien.ac.at

    Affiliation: Department of Dermatology, Medical University of Vienna, Vienna, Austria

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  • Published: September 25, 2012
  • DOI: 10.1371/journal.pone.0046103

About the Authors

Verena Paulitschke, Silke Gruber, Elisabeth Hofstätter, Nikolaus Schicher, Constanze Jonak, Peter Petzelbauer, Hubert Pehamberger, Rainer Kunstfeld
Department of Dermatology, Medical University of Vienna, Vienna, Austria
Verena Haudek-Prinz, Philipp Klepeisz, Christopher Gerner
Department of Medicine I, Medical University of Vienna, Vienna, Austria

Corresponding Author

Email: rainer.kunstfeld@meduniwien.ac.at

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: VP CG PP RK. Performed the experiments: VP SG VHP PK CG EH. Analyzed the data: VP NS CJ HP. Contributed reagents/materials/analysis tools: CG RK PP HP. Wrote the paper: VP RK.