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Research Article

A Novel Plasmid-Encoded Serotype Conversion Mechanism through Addition of Phosphoethanolamine to the O-Antigen of Shigella flexneri

  • Qiangzheng Sun equal contributor,

    equal contributor Contributed equally to this work with: Qiangzheng Sun, Yuriy A. Knirel, Ruiting Lan, Jianping Wang

    Affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, China CDC, Changping, Beijing, China

    X
  • Yuriy A. Knirel equal contributor,

    equal contributor Contributed equally to this work with: Qiangzheng Sun, Yuriy A. Knirel, Ruiting Lan, Jianping Wang

    Affiliation: N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

    X
  • Ruiting Lan equal contributor,

    equal contributor Contributed equally to this work with: Qiangzheng Sun, Yuriy A. Knirel, Ruiting Lan, Jianping Wang

    Affiliation: School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia

    X
  • Jianping Wang equal contributor,

    equal contributor Contributed equally to this work with: Qiangzheng Sun, Yuriy A. Knirel, Ruiting Lan, Jianping Wang

    Affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, China CDC, Changping, Beijing, China

    X
  • Sof’ya N. Senchenkova,

    Affiliation: N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

    X
  • Dong Jin,

    Affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, China CDC, Changping, Beijing, China

    X
  • Alexander S. Shashkov,

    Affiliation: N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

    X
  • Shengli Xia,

    Affiliation: Branch for Enteric Disease Control and Prevention, Institute for Infectious Disease Control and Prevention, Henan Center for Disease Control and Prevention, Zhengzhou, China

    X
  • Andrei V. Perepelov,

    Affiliation: N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

    X
  • Qiang Chen,

    Affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, China CDC, Changping, Beijing, China

    X
  • Yan Wang,

    Affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, China CDC, Changping, Beijing, China

    X
  • Haiyin Wang,

    Affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, China CDC, Changping, Beijing, China

    X
  • Jianguo Xu mail

    xujianguo@icdc.cn

    Affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, China CDC, Changping, Beijing, China

    X
  • Published: September 26, 2012
  • DOI: 10.1371/journal.pone.0046095

About the Authors

Qiangzheng Sun, Jianping Wang, Dong Jin, Qiang Chen, Yan Wang, Haiyin Wang, Jianguo Xu
State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, China CDC, Changping, Beijing, China
Yuriy A. Knirel, Sof’ya N. Senchenkova, Alexander S. Shashkov, Andrei V. Perepelov
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
Ruiting Lan
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia
Shengli Xia
Branch for Enteric Disease Control and Prevention, Institute for Infectious Disease Control and Prevention, Henan Center for Disease Control and Prevention, Zhengzhou, China

Corresponding Author

Email: xujianguo@icdc.cn

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: QS RL JX YAK. Performed the experiments: QS YAK JW SNS DJ ASS SX AVP QC YW HW. Analyzed the data: RL QS YAK JX. Wrote the paper: QS YAK RL JX.