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Research Article

Early Detection of Malignant Pleural Mesothelioma in Asbestos-Exposed Individuals with a Noninvasive Proteomics-Based Surveillance Tool

  • Rachel M. Ostroff equal contributor mail,

    equal contributor Contributed equally to this work with: Rachel M. Ostroff, Michael R. Mehan

    rostroff@somalogic.com

    Affiliation: Clinical Research, SomaLogic Inc., Boulder, Colorado, United States of America

    X
  • Michael R. Mehan equal contributor,

    equal contributor Contributed equally to this work with: Rachel M. Ostroff, Michael R. Mehan

    Affiliation: Clinical Research, SomaLogic Inc., Boulder, Colorado, United States of America

    X
  • Alex Stewart,

    Affiliation: Clinical Research, SomaLogic Inc., Boulder, Colorado, United States of America

    X
  • Deborah Ayers,

    Affiliation: Clinical Research, SomaLogic Inc., Boulder, Colorado, United States of America

    X
  • Edward N. Brody,

    Affiliation: Clinical Research, SomaLogic Inc., Boulder, Colorado, United States of America

    X
  • Stephen A. Williams,

    Affiliation: Clinical Research, SomaLogic Inc., Boulder, Colorado, United States of America

    X
  • Stephen Levin,

    Affiliation: Center for Occupational and Environmental Medicine, Mt. Sinai Medical Center, New York, New York, United States of America

    X
  • Brad Black,

    Affiliation: Center for Asbestos Related Diseases, Libby, Montana, United States of America

    X
  • Michael Harbut,

    Affiliation: Environmental Cancer Program, Karmanos Cancer Center, Detroit, Michigan, United States of America

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  • Michele Carbone,

    Affiliation: Department of Pathology, Cancer Research Center of Hawaii, Honolulu, Hawaii, United States of America

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  • Chandra Goparaju,

    Affiliation: Department of Cardiothoracic Surgery, New York University Langone Medical Center and Cancer Center, New York, New York, United States of America

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  • Harvey I. Pass

    Affiliation: Department of Cardiothoracic Surgery, New York University Langone Medical Center and Cancer Center, New York, New York, United States of America

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  • Published: October 03, 2012
  • DOI: 10.1371/journal.pone.0046091

About the Authors

Rachel M. Ostroff, Michael R. Mehan, Alex Stewart, Deborah Ayers, Edward N. Brody, Stephen A. Williams
Clinical Research, SomaLogic Inc., Boulder, Colorado, United States of America
Stephen Levin
Center for Occupational and Environmental Medicine, Mt. Sinai Medical Center, New York, New York, United States of America
Brad Black
Center for Asbestos Related Diseases, Libby, Montana, United States of America
Michael Harbut
Environmental Cancer Program, Karmanos Cancer Center, Detroit, Michigan, United States of America
Michele Carbone
Department of Pathology, Cancer Research Center of Hawaii, Honolulu, Hawaii, United States of America
Chandra Goparaju, Harvey I. Pass
Department of Cardiothoracic Surgery, New York University Langone Medical Center and Cancer Center, New York, New York, United States of America

Corresponding Author

Email: rostroff@somalogic.com

Competing Interests

RO, MM, AS, DA, EB, and SW are employees of SomaLogic. SomaLogic funded the proteomic analyses. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. The remaining authors have no conflict of interest.

Author Contributions

Conceived and designed the experiments: RO MM AS EB SW HP. Performed the experiments: DA CG. Analyzed the data: RO MM AS EB SW CG HP. Wrote the paper: RO MM AS HP. Study participant recruitment, sample and clinical data collection: SL BB MH HP. Pathologic diagnosis and staging: MC HP.