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Research Article

Functional Polymorphisms of CHRNA3 Predict Risks of Chronic Obstructive Pulmonary Disease and Lung Cancer in Chinese

  • Lei Yang,

    Affiliation: School of Public Health, The Institute for Chemical Carcinogenesis, The State Key Lab of Respiratory Disease, Guangzhou Medical University, Guangzhou, Guangdong, China

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  • Fuman Qiu,

    Affiliation: School of Public Health, The Institute for Chemical Carcinogenesis, The State Key Lab of Respiratory Disease, Guangzhou Medical University, Guangzhou, Guangdong, China

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  • Xiaoxiao Lu,

    Affiliation: School of Public Health, The Institute for Chemical Carcinogenesis, The State Key Lab of Respiratory Disease, Guangzhou Medical University, Guangzhou, Guangdong, China

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  • Dongsheng Huang,

    Affiliations: School of Public Health, The Institute for Chemical Carcinogenesis, The State Key Lab of Respiratory Disease, Guangzhou Medical University, Guangzhou, Guangdong, China, Department of Respiratory Medicine, Guangzhou Chest Hospital, Guangzhou, Guangdong, China

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  • Guanpei Ma,

    Affiliation: School of Public Health, The Institute for Chemical Carcinogenesis, The State Key Lab of Respiratory Disease, Guangzhou Medical University, Guangzhou, Guangdong, China

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  • Yuan Guo,

    Affiliation: The third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China

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  • Min Hu,

    Affiliation: Soochow University Laboratory of Cancer Molecular Genetics, Medical College of Soochow University, Suzhou, China

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  • Yumin Zhou,

    Affiliation: Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital, The State Key Lab of Respiratory Disease, Guangzhou Medical University, Guangzhou, Guangdong, China

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  • Mingan Pan,

    Affiliation: Department of Respiratory Medicine, the third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China

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  • Yigang Tan,

    Affiliation: Department of Respiratory Medicine, Guangzhou Chest Hospital, Guangzhou, Guangdong, China

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  • Haibo Zhong,

    Affiliation: Department of Respiratory Medicine, Guangzhou Red Cross Hospital, Guangzhou, Guangdong, China

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  • Weidong Ji,

    Affiliation: School of Public Health, The Institute for Chemical Carcinogenesis, The State Key Lab of Respiratory Disease, Guangzhou Medical University, Guangzhou, Guangdong, China

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  • Qingyi Wei,

    Affiliation: Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, United States of America

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  • Pixin Ran,

    Affiliation: Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital, The State Key Lab of Respiratory Disease, Guangzhou Medical University, Guangzhou, Guangdong, China

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  • Nanshan Zhong,

    Affiliation: Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital, The State Key Lab of Respiratory Disease, Guangzhou Medical University, Guangzhou, Guangdong, China

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  • Yifeng Zhou,

    Affiliation: Soochow University Laboratory of Cancer Molecular Genetics, Medical College of Soochow University, Suzhou, China

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  • Jiachun Lu mail

    jcLu@gzhmc.edu.cn

    Affiliation: School of Public Health, The Institute for Chemical Carcinogenesis, The State Key Lab of Respiratory Disease, Guangzhou Medical University, Guangzhou, Guangdong, China

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  • Published: October 03, 2012
  • DOI: 10.1371/journal.pone.0046071

About the Authors

Lei Yang, Fuman Qiu, Xiaoxiao Lu, Dongsheng Huang, Guanpei Ma, Weidong Ji, Jiachun Lu
School of Public Health, The Institute for Chemical Carcinogenesis, The State Key Lab of Respiratory Disease, Guangzhou Medical University, Guangzhou, Guangdong, China
Yumin Zhou, Pixin Ran, Nanshan Zhong
Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital, The State Key Lab of Respiratory Disease, Guangzhou Medical University, Guangzhou, Guangdong, China
Dongsheng Huang, Yigang Tan
Department of Respiratory Medicine, Guangzhou Chest Hospital, Guangzhou, Guangdong, China
Yuan Guo
The third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
Mingan Pan
Department of Respiratory Medicine, the third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
Haibo Zhong
Department of Respiratory Medicine, Guangzhou Red Cross Hospital, Guangzhou, Guangdong, China
Min Hu, Yifeng Zhou
Soochow University Laboratory of Cancer Molecular Genetics, Medical College of Soochow University, Suzhou, China
Qingyi Wei
Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, United States of America

Corresponding Author

Email: jcLu@gzhmc.edu.cn

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JCL. Performed the experiments: LY FMQ XXL. Analyzed the data: LY GPM. Contributed reagents/materials/analysis tools: DSH YG MH YMZ MGP YGT HBZ. Wrote the paper: LY JCL. Revision of the paper: WDJ QYW PXR NSZ YFZ.