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Research Article

Chemical Analysis and Transplacental Transfer of Oseltamivir and Oseltamivir Carboxylic Acid in Pregnant Rats

  • Chia-Chun Lin,

    Affiliation: Institute of Pharmacology, School of Medicine, National Yang-Ming University, Taipei, Taiwan

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  • Jiin-Cherng Yen,

    Affiliation: Institute of Pharmacology, School of Medicine, National Yang-Ming University, Taipei, Taiwan

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  • Yu-Tse Wu,

    Affiliations: Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan, Department of Education and Research, Taipei City Hospital, Taipei, Taiwan

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  • Lie-Chwen Lin,

    Affiliations: Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan, National Research Institute of Chinese Medicine, Taipei, Taiwan

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  • Tung-Hu Tsai mail

    thtsai@ym.edu.tw

    Affiliations: Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan, Graduate Institute of Acupuncture Science, China Medical University, Taichung, Taiwan, Department of Education and Research, Taipei City Hospital, Taipei, Taiwan

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  • Published: October 03, 2012
  • DOI: 10.1371/journal.pone.0046062

About the Authors

Chia-Chun Lin, Jiin-Cherng Yen
Institute of Pharmacology, School of Medicine, National Yang-Ming University, Taipei, Taiwan
Yu-Tse Wu, Lie-Chwen Lin, Tung-Hu Tsai
Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan
Lie-Chwen Lin
National Research Institute of Chinese Medicine, Taipei, Taiwan
Tung-Hu Tsai
Graduate Institute of Acupuncture Science, China Medical University, Taichung, Taiwan
Yu-Tse Wu, Tung-Hu Tsai
Department of Education and Research, Taipei City Hospital, Taipei, Taiwan

Corresponding Author

Email: thtsai@ym.edu.tw

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CCL THT. Performed the experiments: CCL JCY YTW LCL. Analyzed the data: CCL THT. Wrote the paper: CCL THT.