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Research Article

Lovastatin Induces Multiple Stress Pathways Including LKB1/AMPK Activation That Regulate Its Cytotoxic Effects in Squamous Cell Carcinoma Cells

  • Laurie Ma,

    Affiliation: Centre for Cancer Therapeutics, The Ottawa Hospital Research Institute, Ontario, Canada

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  • Nima Niknejad,

    Affiliation: Centre for Cancer Therapeutics, The Ottawa Hospital Research Institute, Ontario, Canada

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  • Ivan Gorn-Hondermann,

    Affiliation: Centre for Cancer Therapeutics, The Ottawa Hospital Research Institute, Ontario, Canada

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  • Khalil Dayekh,

    Affiliations: Centre for Cancer Therapeutics, The Ottawa Hospital Research Institute, Ontario, Canada, The Faculty of Medicine and the Department of Biochemistry, University of Ottawa, Ontario, Canada

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  • Jim Dimitroulakos mail

    jdimitroulakos@ohri.ca

    Affiliations: Centre for Cancer Therapeutics, The Ottawa Hospital Research Institute, Ontario, Canada, The Faculty of Medicine and the Department of Biochemistry, University of Ottawa, Ontario, Canada

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  • Published: September 28, 2012
  • DOI: 10.1371/journal.pone.0046055

About the Authors

Laurie Ma, Nima Niknejad, Ivan Gorn-Hondermann, Khalil Dayekh, Jim Dimitroulakos
Centre for Cancer Therapeutics, The Ottawa Hospital Research Institute, Ontario, Canada
Khalil Dayekh, Jim Dimitroulakos
The Faculty of Medicine and the Department of Biochemistry, University of Ottawa, Ontario, Canada

Corresponding Author

Email: jdimitroulakos@ohri.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LM NN JD. Performed the experiments: LM NN IGH KD. Analyzed the data: LM NN JD. Wrote the paper: LM NN JD.