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Research Article

Statistical Analysis of Individual Participant Data Meta-Analyses: A Comparison of Methods and Recommendations for Practice

  • Gavin B. Stewart mail,

    gavin.stewart@york.ac.uk

    Affiliation: Centre for Reviews and Dissemination, University of York, York, United Kingdom

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  • Douglas G. Altman,

    Affiliation: Centre for Statistics in Medicine, University of Oxford, Oxford, United Kingdom

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  • Lisa M. Askie,

    Affiliation: NHMRC Clinical Trials Centre, University of Sydney, Sydney, Australia

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  • Lelia Duley,

    Affiliation: Nottingham Clinical Trials Unit, University of Nottingham, Nottingham, United Kingdom

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  • Mark C. Simmonds,

    Affiliation: Centre for Reviews and Dissemination, University of York, York, United Kingdom

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  • Lesley A. Stewart

    Affiliation: Centre for Reviews and Dissemination, University of York, York, United Kingdom

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  • Published: October 03, 2012
  • DOI: 10.1371/journal.pone.0046042

About the Authors

Gavin B. Stewart, Mark C. Simmonds, Lesley A. Stewart
Centre for Reviews and Dissemination, University of York, York, United Kingdom
Douglas G. Altman
Centre for Statistics in Medicine, University of Oxford, Oxford, United Kingdom
Lisa M. Askie
NHMRC Clinical Trials Centre, University of Sydney, Sydney, Australia
Lelia Duley
Nottingham Clinical Trials Unit, University of Nottingham, Nottingham, United Kingdom

Corresponding Author

Email: gavin.stewart@york.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GS DA LA LD MS LS. Performed the experiments: GS MS. Analyzed the data: GS DA LA LD MS LS. Contributed reagents/materials/analysis tools: GS MS. Wrote the paper: GS DA LA LD MS LS.