About the Authors

Elena Chiappini

echiappini@unifi.it

Affiliation Anna Meyer University Hospital, Department of Science for Woman and Child Health, University of Florence, Florence, Italy

Chiara Della Bella

Affiliation Department of Internal Medicine, University of Florence, Florence, Italy

Francesca Bonsignori

Affiliation Anna Meyer University Hospital, Department of Science for Woman and Child Health, University of Florence, Florence, Italy

Sara Sollai

Affiliation Anna Meyer University Hospital, Department of Science for Woman and Child Health, University of Florence, Florence, Italy

Amedeo Amedei

Affiliation Department of Internal Medicine, University of Florence, Florence, Italy

Luisa Galli

Affiliation Anna Meyer University Hospital, Department of Science for Woman and Child Health, University of Florence, Florence, Italy

Elena Niccolai

Affiliation Department of Internal Medicine, University of Florence, Florence, Italy

Gianfranco Del Prete

† Deceased.

Affiliation Department of Internal Medicine, University of Florence, Florence, Italy

Mahavir Singh

Affiliation Lionex GmbH, Braunschweig, Germany

Mario M. D'Elios

Affiliation Department of Internal Medicine, University of Florence, Florence, Italy

Maurizio de Martino

Affiliation Anna Meyer University Hospital, Department of Science for Woman and Child Health, University of Florence, Florence, Italy

Competing Interests

MS is the owner and director of commercial company Lionex GmbH, Braunschweig, Germany. Lionex has not provided any financial support for the research mentioned in the manuscript. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. All other authors do not have a commercial or other association that might pose a conflict of interest.

Author Contributions

Performed the experiments: MdM CDB MMD AA EN MS. Analyzed the data: EC FB LG. Contributed reagents/materials/analysis tools: MdM CDB MMD. Wrote the paper: EC MMD MdM FB. Performed data collection, analysis and wrote the draft: EC GFDP CDB MdM. Supervised the project: MdM. Performed data collection and analysis: LG FB SS. Commented on and approved the final draft: EC CDB FB SS AA LG EN GFDP MS MMD MdM.