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Research Article

Potential Role of M. tuberculosis Specific IFN-γ and IL-2 ELISPOT Assays in Discriminating Children with Active or Latent Tuberculosis

  • Elena Chiappini mail,

    echiappini@unifi.it

    Affiliation: Anna Meyer University Hospital, Department of Science for Woman and Child Health, University of Florence, Florence, Italy

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  • Chiara Della Bella,

    Affiliation: Department of Internal Medicine, University of Florence, Florence, Italy

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  • Francesca Bonsignori,

    Affiliation: Anna Meyer University Hospital, Department of Science for Woman and Child Health, University of Florence, Florence, Italy

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  • Sara Sollai,

    Affiliation: Anna Meyer University Hospital, Department of Science for Woman and Child Health, University of Florence, Florence, Italy

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  • Amedeo Amedei,

    Affiliation: Department of Internal Medicine, University of Florence, Florence, Italy

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  • Luisa Galli,

    Affiliation: Anna Meyer University Hospital, Department of Science for Woman and Child Health, University of Florence, Florence, Italy

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  • Elena Niccolai,

    Affiliation: Department of Internal Medicine, University of Florence, Florence, Italy

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  • Gianfranco Del Prete †,

    † Deceased.

    Affiliation: Department of Internal Medicine, University of Florence, Florence, Italy

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  • Mahavir Singh,

    Affiliation: Lionex GmbH, Braunschweig, Germany

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  • Mario M. D'Elios,

    Affiliation: Department of Internal Medicine, University of Florence, Florence, Italy

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  • Maurizio de Martino

    Affiliation: Anna Meyer University Hospital, Department of Science for Woman and Child Health, University of Florence, Florence, Italy

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  • Published: September 28, 2012
  • DOI: 10.1371/journal.pone.0046041

About the Authors

Elena Chiappini, Francesca Bonsignori, Sara Sollai, Luisa Galli, Maurizio de Martino
Anna Meyer University Hospital, Department of Science for Woman and Child Health, University of Florence, Florence, Italy
Chiara Della Bella, Amedeo Amedei, Elena Niccolai, Gianfranco Del Prete, Mario M. D'Elios
Department of Internal Medicine, University of Florence, Florence, Italy
Mahavir Singh
Lionex GmbH, Braunschweig, Germany

Corresponding Author

Email: echiappini@unifi.it

Competing Interests

MS is the owner and director of commercial company Lionex GmbH, Braunschweig, Germany. Lionex has not provided any financial support for the research mentioned in the manuscript. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. All other authors do not have a commercial or other association that might pose a conflict of interest.

Author Contributions

Performed the experiments: MdM CDB MMD AA EN MS. Analyzed the data: EC FB LG. Contributed reagents/materials/analysis tools: MdM CDB MMD. Wrote the paper: EC MMD MdM FB. Performed data collection, analysis and wrote the draft: EC GFDP CDB MdM. Supervised the project: MdM. Performed data collection and analysis: LG FB SS. Commented on and approved the final draft: EC CDB FB SS AA LG EN GFDP MS MMD MdM.