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Research Article

Aquaporin-1 Translocation and Degradation Mediates the Water Transportation Mechanism of Acetazolamide

  • Jianzhao Zhang equal contributor,

    equal contributor Contributed equally to this work with: Jianzhao Zhang, Yu An

    Affiliations: State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China, Institute of Systems Biomedicine, Peking University, Beijing, China

    X
  • Yu An equal contributor,

    equal contributor Contributed equally to this work with: Jianzhao Zhang, Yu An

    Affiliations: State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China, Institute of Systems Biomedicine, Peking University, Beijing, China

    X
  • Junwei Gao,

    Affiliation: State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China

    X
  • Jing Han,

    Affiliations: State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China, Institute of Systems Biomedicine, Peking University, Beijing, China

    X
  • Xueyang Pan,

    Affiliations: State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China, Institute of Systems Biomedicine, Peking University, Beijing, China

    X
  • Yan Pan,

    Affiliations: State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China, Institute of Systems Biomedicine, Peking University, Beijing, China

    X
  • Lu Tie,

    Affiliations: State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China, Institute of Systems Biomedicine, Peking University, Beijing, China

    X
  • Xuejun Li mail

    lixj@bjmu.edu.cn

    Affiliations: State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China, Institute of Systems Biomedicine, Peking University, Beijing, China

    X
  • Published: September 21, 2012
  • DOI: 10.1371/journal.pone.0045976

About the Authors

Jianzhao Zhang, Yu An, Junwei Gao, Jing Han, Xueyang Pan, Yan Pan, Lu Tie, Xuejun Li
State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China
Jianzhao Zhang, Yu An, Jing Han, Xueyang Pan, Yan Pan, Lu Tie, Xuejun Li
Institute of Systems Biomedicine, Peking University, Beijing, China

Corresponding Author

Email: lixj@bjmu.edu.cn

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JZ YA XL. Performed the experiments: JZ YA JG JH XP. Analyzed the data: JZ YA LT XL. Contributed reagents/materials/analysis tools: LT YP. Wrote the paper: JZ YA XL.