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Research Article

Development of a Non-Invasive Method, Multiplex Methylation Specific PCR (MMSP), for Early Diagnosis of Nasopharyngeal Carcinoma

  • Zhe Zhang equal contributor,

    equal contributor Contributed equally to this work with: Zhe Zhang, Di Sun

    Affiliations: Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden, Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China

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  • Di Sun equal contributor,

    equal contributor Contributed equally to this work with: Zhe Zhang, Di Sun

    Affiliations: Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden, Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China

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  • Susanna Hilda Hutajulu,

    Affiliation: Molecular Biology, Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia

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  • Imran Nawaz,

    Affiliation: Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden

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  • Do Nguyen Van,

    Affiliations: Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden, Department of Immunology and Pathophysiology, Hanoi Medical University (HMU), Dongda, Hanoi, Vietnam

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  • Guangwu Huang,

    Affiliation: Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China

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  • Sofia M. Haryana,

    Affiliation: Molecular Biology, Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia

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  • Jaap M. Middeldorp,

    Affiliation: Department of Pathology, VU Medical Center, Amsterdam, The Netherlands

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  • Ingemar Ernberg,

    Affiliation: Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden

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  • Li-Fu Hu mail

    lifu.hu@ki.se

    Affiliation: Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden

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  • Published: November 05, 2012
  • DOI: 10.1371/journal.pone.0045908

About the Authors

Zhe Zhang, Di Sun, Imran Nawaz, Do Nguyen Van, Ingemar Ernberg, Li-Fu Hu
Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden
Zhe Zhang, Di Sun, Guangwu Huang
Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China
Susanna Hilda Hutajulu, Sofia M. Haryana
Molecular Biology, Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia
Jaap M. Middeldorp
Department of Pathology, VU Medical Center, Amsterdam, The Netherlands
Do Nguyen Van
Department of Immunology and Pathophysiology, Hanoi Medical University (HMU), Dongda, Hanoi, Vietnam

Corresponding Author

Email: lifu.hu@ki.se

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: IE LH. Performed the experiments: ZZ DS SHH IN DNV GH SMH. Analyzed the data: ZZ DS LH. Contributed reagents/materials/analysis tools: LH. Wrote the paper: ZZ DS JMM IE LH.