About the Authors

Julie A. Harris

Affiliations Gladstone Institute of Neurological Disease, San Francisco, California, United States of America, Department of Neurology, University of California San Francisco, San Francisco, California, United States of America

Akihiko Koyama

Affiliation Gladstone Institute of Neurological Disease, San Francisco, California, United States of America

Sumihiro Maeda

Affiliations Gladstone Institute of Neurological Disease, San Francisco, California, United States of America, Department of Neurology, University of California San Francisco, San Francisco, California, United States of America

Kaitlyn Ho

Affiliation Gladstone Institute of Neurological Disease, San Francisco, California, United States of America

Nino Devidze

Affiliation Gladstone Institute of Neurological Disease, San Francisco, California, United States of America

Dena B. Dubal

Affiliations Gladstone Institute of Neurological Disease, San Francisco, California, United States of America, Department of Neurology, University of California San Francisco, San Francisco, California, United States of America

Gui-Qiu Yu

Affiliation Gladstone Institute of Neurological Disease, San Francisco, California, United States of America

Eliezer Masliah

Affiliations Department of Neurosciences, University of California San Diego, La Jolla, California, United States of America, Department of Pathology, University of California San Diego, La Jolla, California, United States of America

Lennart Mucke

lmucke@gladstone.ucsf.edu

Affiliations Gladstone Institute of Neurological Disease, San Francisco, California, United States of America, Department of Neurology, University of California San Francisco, San Francisco, California, United States of America

Competing Interests

Dr. Mucke is a member of the scientific advisory boards of AgeneBio, iPierian, ProBiodrug and Neuropore Therapies. He has received research funding for other projects and consulting fees from Bristol-Myers Squibb. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JAH AK SM LM. Performed the experiments: JAH AK SM KH ND DBD GY EM. Analyzed the data: JAH AK SM ND DBD EM LM. Wrote the paper: JAH SM LM. Coordinated the study: JAH. Supervised the study: LM.