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Research Article

Dimethylfumarate Attenuates Renal Fibrosis via NF-E2-Related Factor 2-Mediated Inhibition of Transforming Growth Factor-β/Smad Signaling

  • Chang Joo Oh,

    Affiliation: Departments of Internal Medicine, Research Institute of Aging and Metabolism, WCU Program, Kyungpook National University School of Medicine, Daegu, Republic of Korea

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  • Joon-Young Kim,

    Affiliations: Departments of Internal Medicine, Research Institute of Aging and Metabolism, WCU Program, Kyungpook National University School of Medicine, Daegu, Republic of Korea, GIST College, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea

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  • Young-Keun Choi,

    Affiliation: Departments of Internal Medicine, Research Institute of Aging and Metabolism, WCU Program, Kyungpook National University School of Medicine, Daegu, Republic of Korea

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  • Han-Jong Kim,

    Affiliations: Departments of Internal Medicine, Research Institute of Aging and Metabolism, WCU Program, Kyungpook National University School of Medicine, Daegu, Republic of Korea, Research Institute of Clinical Medicine, Chonnam National University Hwasun Hospital, Hwasun, Republic of Korea

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  • Ji-Yun Jeong,

    Affiliation: Departments of Internal Medicine, Research Institute of Aging and Metabolism, WCU Program, Kyungpook National University School of Medicine, Daegu, Republic of Korea

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  • Kwi-Hyun Bae,

    Affiliation: Departments of Internal Medicine, Research Institute of Aging and Metabolism, WCU Program, Kyungpook National University School of Medicine, Daegu, Republic of Korea

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  • Keun-Gyu Park,

    Affiliation: Departments of Internal Medicine, Research Institute of Aging and Metabolism, WCU Program, Kyungpook National University School of Medicine, Daegu, Republic of Korea

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  • In-Kyu Lee mail

    leei@knu.ac.kr

    Affiliation: Departments of Internal Medicine, Research Institute of Aging and Metabolism, WCU Program, Kyungpook National University School of Medicine, Daegu, Republic of Korea

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  • Published: October 08, 2012
  • DOI: 10.1371/journal.pone.0045870

About the Authors

Chang Joo Oh, Joon-Young Kim, Young-Keun Choi, Han-Jong Kim, Ji-Yun Jeong, Kwi-Hyun Bae, Keun-Gyu Park, In-Kyu Lee
Departments of Internal Medicine, Research Institute of Aging and Metabolism, WCU Program, Kyungpook National University School of Medicine, Daegu, Republic of Korea
Joon-Young Kim
GIST College, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea
Han-Jong Kim
Research Institute of Clinical Medicine, Chonnam National University Hwasun Hospital, Hwasun, Republic of Korea

Corresponding Author

Email: leei@knu.ac.kr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CJO JYK HJK KGP IKL. Performed the experiments: CJO YKC. Analyzed the data: CJO JYK HJK KGP IKL. Contributed reagents/materials/analysis tools: JYK YKC HJK JYJ KHB KGP IKL. Wrote the paper: CJO KGP JYK IKL.