About the Authors

Bastiaan A. van den Berg

b.a.vandenberg@tudelft.nl

Affiliations Delft Bioinformatics Lab, Department of Intelligent Systems, Faculty Electrical Engineering, Mathematics and Computer Science, Delft University of Technology, Delft, The Netherlands, Netherlands Bioinformatics Centre, Nijmegen, The Netherlands, Kluyver Centre for Genomics of Industrial Fermentation, Delft, The Netherlands

Marcel J. T. Reinders

Affiliations Delft Bioinformatics Lab, Department of Intelligent Systems, Faculty Electrical Engineering, Mathematics and Computer Science, Delft University of Technology, Delft, The Netherlands, Netherlands Bioinformatics Centre, Nijmegen, The Netherlands, Kluyver Centre for Genomics of Industrial Fermentation, Delft, The Netherlands

Marc Hulsman

Affiliations Delft Bioinformatics Lab, Department of Intelligent Systems, Faculty Electrical Engineering, Mathematics and Computer Science, Delft University of Technology, Delft, The Netherlands, Netherlands Bioinformatics Centre, Nijmegen, The Netherlands, Kluyver Centre for Genomics of Industrial Fermentation, Delft, The Netherlands

Liang Wu

Affiliation DSM Biotechnology Center, Delft, The Netherlands

Herman J. Pel

Affiliation DSM Biotechnology Center, Delft, The Netherlands

Johannes A. Roubos

Affiliation DSM Biotechnology Center, Delft, The Netherlands

Dick de Ridder

Affiliations Delft Bioinformatics Lab, Department of Intelligent Systems, Faculty Electrical Engineering, Mathematics and Computer Science, Delft University of Technology, Delft, The Netherlands, Netherlands Bioinformatics Centre, Nijmegen, The Netherlands, Kluyver Centre for Genomics of Industrial Fermentation, Delft, The Netherlands

Competing Interests

DSM is a Life Sciences and Material Sciences company with enzyme products in its portfolio. Three of the co-authors, JAR, HP, and LW, are DSM employees. IP on this or related work might be filed. The used data set was provided by DSM Biotechnology Center. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: BAB DR MJTR JAR MH HJP LW. Performed the experiments: BAB. Analyzed the data: BAB DR MJTR JAR. Contributed reagents/materials/analysis tools: BAB MH. Wrote the paper: BAB DR JAR MJTR.