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Research Article

Low-Dose Oral Sirolimus and the Risk of Menstrual-Cycle Disturbances and Ovarian Cysts: Analysis of the Randomized Controlled SUISSE ADPKD Trial

  • Matthias Braun,

    Affiliation: Division of Nephrology, University Hospital, Zürich, Switzerland

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  • James Young,

    Affiliation: Biometrical Practice BIOP AG, Basel, Switzerland

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  • Cäcilia S. Reiner,

    Affiliation: Division of Diagnostic and Interventional Radiology, University Hospital, Zürich, Switzerland

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  • Diane Poster,

    Affiliation: Division of Nephrology, University Hospital, Zürich, Switzerland

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  • Fabienne Krauer,

    Affiliation: Division of Nephrology, University Hospital, Zürich, Switzerland

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  • Andreas D. Kistler,

    Affiliation: Division of Nephrology, University Hospital, Zürich, Switzerland

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  • Paulus Kristanto,

    Affiliation: Medication Adherence Research Centre, AARDEX Group, Visé, Belgium

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  • Xueqi Wang,

    Affiliation: Department of Nephrology, Changzheng Hospital, Shanghai, China

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  • Yang Liu,

    Affiliation: Center for Integrative Human Research, University of Zürich, Zürich, Switzerland

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  • Johannes Loffing,

    Affiliation: Institute of Anatomy, University of Zürich, Zürich, Switzerland

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  • Gustav Andreisek,

    Affiliation: Division of Diagnostic and Interventional Radiology, University Hospital, Zürich, Switzerland

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  • Arnold von Eckardstein,

    Affiliation: Institute of Clinical Chemistry, University Hospital, Zürich, Switzerland

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  • Oliver Senn,

    Affiliation: Institute of General Practice and Health Services Research, University Hospital, Zürich, Switzerland

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  • Rudolf P. Wüthrich,

    Affiliation: Division of Nephrology, University Hospital, Zürich, Switzerland

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  • Andreas L. Serra mail

    andreas.serra@usz.ch

    Affiliation: Division of Nephrology, University Hospital, Zürich, Switzerland

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  • Published: October 10, 2012
  • DOI: 10.1371/journal.pone.0045868

About the Authors

Matthias Braun, Diane Poster, Fabienne Krauer, Andreas D. Kistler, Rudolf P. Wüthrich, Andreas L. Serra
Division of Nephrology, University Hospital, Zürich, Switzerland
James Young
Biometrical Practice BIOP AG, Basel, Switzerland
Cäcilia S. Reiner, Gustav Andreisek
Division of Diagnostic and Interventional Radiology, University Hospital, Zürich, Switzerland
Paulus Kristanto
Medication Adherence Research Centre, AARDEX Group, Visé, Belgium
Xueqi Wang
Department of Nephrology, Changzheng Hospital, Shanghai, China
Yang Liu
Center for Integrative Human Research, University of Zürich, Zürich, Switzerland
Johannes Loffing
Institute of Anatomy, University of Zürich, Zürich, Switzerland
Arnold von Eckardstein
Institute of Clinical Chemistry, University Hospital, Zürich, Switzerland
Oliver Senn
Institute of General Practice and Health Services Research, University Hospital, Zürich, Switzerland

Corresponding Author

Email: andreas.serra@usz.ch

Competing Interests

ALS received consulting fees from Hoffmann–La Roche and Nycomed, and grant support from Wyeth (now Pfizer); DP received travel support from Wyeth (now Pfizer); ADK received lecture fees from Wyeth and Genzyme, and travel support from Amgen; JY is an employee of Biometrical Practice BIOP; PK is an employee of Aardex; RPW received consulting and lecture fees from Genzyme, Novartis and Wyeth, and grant support from Wyeth. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: ALS DP ADK RPW. Performed the experiments: MB CSR FK PK XW YL JL GA AE. Analyzed the data: ALS JY OS. Contributed reagents/materials/analysis tools: JL. Wrote the paper: MB JY ALS RPW.