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Research Article

Neutrophil Gelatinase-Associated Lipocalin (NGAL) Predicts Response to Neoadjuvant Chemotherapy and Clinical Outcome in Primary Human Breast Cancer

  • Antonia Sophie Wenners mail,

    antonia.wenners@uk-sh.de

    Affiliation: Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, Kiel, Germany

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  • Keyur Mehta,

    Affiliation: German Breast Group, GBG ForschungsGmbH, Neu-Isenburg, Germany

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  • Sibylle Loibl,

    Affiliation: German Breast Group, GBG ForschungsGmbH, Neu-Isenburg, Germany

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  • Hyerim Park,

    Affiliation: Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, Kiel, Germany

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  • Berit Mueller,

    Affiliation: Translational Tumorpathology Unit, Institute of Pathology, Charité, Berlin, Germany

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  • Norbert Arnold,

    Affiliation: Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, Kiel, Germany

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  • Sigrid Hamann,

    Affiliation: Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, Kiel, Germany

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  • Joerg Weimer,

    Affiliation: Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, Kiel, Germany

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  • Beyhan Ataseven,

    Affiliation: Department of Obstetrics and Gynaecology, Rot-Kreuz-Klinikum Muenchen, Munich, Germany

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  • Silvia Darb-Esfahani,

    Affiliation: Translational Tumorpathology Unit, Institute of Pathology, Charité, Berlin, Germany

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  • Christian Schem,

    Affiliation: Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, Kiel, Germany

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  • Christoph Mundhenke,

    Affiliation: Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, Kiel, Germany

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  • Fariba Khandan,

    Affiliation: St. Markus Hospital, Frankfurt am Main, Germany

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  • Christoph Thomssen,

    Affiliation: Department of Gynecology, Martin-Luther-University of Halle-Wittenberg, Halle, Germany

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  • Walter Jonat,

    Affiliation: Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, Kiel, Germany

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  • Hans-Juergen Holzhausen,

    Affiliation: Department of Pathology, Martin Luther University of Halle–Wittenberg, Halle, Germany

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  • Gunther von Minckwitz,

    Affiliation: German Breast Group, GBG ForschungsGmbH, Neu-Isenburg, Germany

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  • Carsten Denkert,

    Affiliation: Translational Tumorpathology Unit, Institute of Pathology, Charité, Berlin, Germany

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  • Maret Bauer

    Affiliation: Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, Kiel, Germany

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  • Published: October 09, 2012
  • DOI: 10.1371/journal.pone.0045826

About the Authors

Antonia Sophie Wenners, Hyerim Park, Norbert Arnold, Sigrid Hamann, Joerg Weimer, Christian Schem, Christoph Mundhenke, Walter Jonat, Maret Bauer
Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, Kiel, Germany
Keyur Mehta, Sibylle Loibl, Gunther von Minckwitz
German Breast Group, GBG ForschungsGmbH, Neu-Isenburg, Germany
Beyhan Ataseven
Department of Obstetrics and Gynaecology, Rot-Kreuz-Klinikum Muenchen, Munich, Germany
Fariba Khandan
St. Markus Hospital, Frankfurt am Main, Germany
Berit Mueller, Silvia Darb-Esfahani, Carsten Denkert
Translational Tumorpathology Unit, Institute of Pathology, Charité, Berlin, Germany
Christoph Thomssen
Department of Gynecology, Martin-Luther-University of Halle-Wittenberg, Halle, Germany
Hans-Juergen Holzhausen
Department of Pathology, Martin Luther University of Halle–Wittenberg, Halle, Germany

Corresponding Author

Email: antonia.wenners@uk-sh.de

Competing Interests

The authors have read the journal's policy and have the following conflicts: CT received remuneration from Sanofi-Aventis, Roche and Pierre-Fabre, he played a consultant/advisory role for Sanofi-Aventis and Roche. BA was a speaker for Sanofi-Aventis. WJ was consultant for Roche and Novartis. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AW HP SH JW MB. Performed the experiments: HP MB. Analyzed the data: KM SL AW MB BM SD. Contributed reagents/materials/analysis tools: NA BA CS FK CT WJ HH GM CD CM. Wrote the paper: AW MB.