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Research Article

An Extract of Crataegus pinnatifida Fruit Attenuates Airway Inflammation by Modulation of Matrix Metalloproteinase-9 in Ovalbumin Induced Asthma

  • In Sik Shin equal contributor,

    equal contributor Contributed equally to this work with: In Sik Shin, Mee Young Lee

    Affiliations: Basic Herbal Medicine Research Group, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea, College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea

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  • Mee Young Lee equal contributor,

    equal contributor Contributed equally to this work with: In Sik Shin, Mee Young Lee

    Affiliation: Basic Herbal Medicine Research Group, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea

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  • Hye Sun Lim,

    Affiliation: Basic Herbal Medicine Research Group, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea

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  • Hyekyung Ha,

    Affiliation: Basic Herbal Medicine Research Group, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea

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  • Chang Seob Seo,

    Affiliation: Basic Herbal Medicine Research Group, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea

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  • Jong-Choon Kim mail,

    hkshin@kiom.re.kr (HKS); toxkim@chonnam.ac.kr (JCK)

    Affiliation: College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea

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  • Hyeun Kyoo Shin mail

    hkshin@kiom.re.kr (HKS); toxkim@chonnam.ac.kr (JCK)

    Affiliation: Basic Herbal Medicine Research Group, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea

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  • Published: September 21, 2012
  • DOI: 10.1371/journal.pone.0045734

About the Authors

In Sik Shin, Mee Young Lee, Hye Sun Lim, Hyekyung Ha, Chang Seob Seo, Hyeun Kyoo Shin
Basic Herbal Medicine Research Group, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea
In Sik Shin, Jong-Choon Kim
College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ISS MYL JCK HKS. Performed the experiments: ISS MYL HSL. Analyzed the data: ISS MYL. Contributed reagents/materials/analysis tools: HH HKS CSS. Wrote the paper: ISS MYL.