About the Authors

Ganapati V. Hegde

Affiliation Department of Discovery Oncology, Genentech, Inc., South San Francisco, California, United States of America

Cecile de la Cruz

Affiliation Department of Discovery Oncology, Genentech, Inc., South San Francisco, California, United States of America

Jeffrey Eastham-Anderson

Affiliation Department of Pathology, Genentech, Inc., South San Francisco, California, United States of America

Yanyan Zheng

Affiliation Cancer Biology Program, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, United States of America

E. Alejandro Sweet-Cordero

Affiliation Cancer Biology Program, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, United States of America

Erica L. Jackson

ericaj@gene.com

Affiliation Department of Discovery Oncology, Genentech, Inc., South San Francisco, California, United States of America

Competing Interests

The authors have the following competing interest: Ganapati V.Hegde, Cecile de la Cruz and Erica L. Jackson were full-time employees of Genentech, Inc. at the time this work was completed, and Genentech, Inc. was the funder of this study. There are no patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: ELJ GVH. Performed the experiments: ELJ GVH CCDLC YZ. Analyzed the data: GVH CCDLC ELJ JEA. Contributed reagents/materials/analysis tools: GVH ELJ EASC YZ. Wrote the paper: GVH ELJ.