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Research Article

Characterization and Therapeutic Potential of Induced Pluripotent Stem Cell-Derived Cardiovascular Progenitor Cells

  • Ali Nsair equal contributor mail,

    equal contributor Contributed equally to this work with: Ali Nsair, Katja Schenke-Layland

    ansair@mednet.ucla.edu

    Affiliations: Department of Medicine and Physiology, Cardiovascular Research Laboratory, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, The Edythe and Eli Broad Center for Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • Katja Schenke-Layland equal contributor,

    equal contributor Contributed equally to this work with: Ali Nsair, Katja Schenke-Layland

    Affiliations: Department of Medicine and Physiology, Cardiovascular Research Laboratory, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, Department of Cell and Tissue Engineering, Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Stuttgart, Germany, Department of Thoracic and Cardiovascular Surgery, Eberhard Karls University, Tübingen, Germany

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  • Ben Van Handel,

    Affiliations: Department of Molecular, Cell and Developmental Biology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, The Edythe and Eli Broad Center for Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • Denis Evseenko,

    Affiliations: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, The Edythe and Eli Broad Center for Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • Michael Kahn,

    Affiliation: Department of Biochemistry and Molecular Biology and Institute for Stem Cell and Regenerative Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Peng Zhao,

    Affiliation: Department of Medicine and Physiology, Cardiovascular Research Laboratory, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • Joseph Mendelis,

    Affiliation: Department of Medicine and Physiology, Cardiovascular Research Laboratory, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • Sanaz Heydarkhan,

    Affiliation: Department of Medicine and Physiology, Cardiovascular Research Laboratory, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

    Current address: Department of Medicine and Physiology, Cardiovascular Research Laboratory, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • Obina Awaji,

    Affiliation: Department of Medicine and Physiology, Cardiovascular Research Laboratory, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

    Current address: Department of Medicine and Physiology, Cardiovascular Research Laboratory, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • Miriam Vottler,

    Affiliations: Department of Cell and Tissue Engineering, Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Stuttgart, Germany, Department of Thoracic and Cardiovascular Surgery, Eberhard Karls University, Tübingen, Germany

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  • Susanne Geist,

    Affiliations: Department of Cell and Tissue Engineering, Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Stuttgart, Germany, Department of Thoracic and Cardiovascular Surgery, Eberhard Karls University, Tübingen, Germany

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  • Jennifer Chyu,

    Affiliation: Department of Medicine and Physiology, Cardiovascular Research Laboratory, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • Nuria Gago-Lopez,

    Affiliation: Department of Medicine and Physiology, Cardiovascular Research Laboratory, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • Gay M. Crooks,

    Affiliations: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, The Edythe and Eli Broad Center for Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • Kathrin Plath,

    Affiliation: The Edythe and Eli Broad Center for Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • Josh Goldhaber,

    Affiliation: Cedars-Sinai Heart Institute, Los Angeles, California, United States of America

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  • Hanna K. A. Mikkola,

    Affiliations: Department of Molecular, Cell and Developmental Biology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, The Edythe and Eli Broad Center for Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • W. Robb MacLellan

    Affiliation: Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington, United States of America

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  • Published: October 09, 2012
  • DOI: 10.1371/journal.pone.0045603

About the Authors

Ali Nsair, Katja Schenke-Layland, Peng Zhao, Joseph Mendelis, Sanaz Heydarkhan, Obina Awaji, Jennifer Chyu, Nuria Gago-Lopez
Department of Medicine and Physiology, Cardiovascular Research Laboratory, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
Katja Schenke-Layland, Miriam Vottler, Susanne Geist
Department of Cell and Tissue Engineering, Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Stuttgart, Germany
Katja Schenke-Layland, Miriam Vottler, Susanne Geist
Department of Thoracic and Cardiovascular Surgery, Eberhard Karls University, Tübingen, Germany
Denis Evseenko, Gay M. Crooks
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
Ben Van Handel, Hanna K. A. Mikkola
Department of Molecular, Cell and Developmental Biology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
Ali Nsair, Ben Van Handel, Denis Evseenko, Gay M. Crooks, Kathrin Plath, Hanna K. A. Mikkola
The Edythe and Eli Broad Center for Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
Josh Goldhaber
Cedars-Sinai Heart Institute, Los Angeles, California, United States of America
Michael Kahn
Department of Biochemistry and Molecular Biology and Institute for Stem Cell and Regenerative Medicine, University of Southern California, Los Angeles, California, United States of America
W. Robb MacLellan
Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington, United States of America

Corresponding Author

Email: ansair@mednet.ucla.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AN KSL BVH HKAM KP GMC WRM. Performed the experiments: AN KSL BVH PZ NGL JC MV SG SH OA. Analyzed the data: AN KSL BVH DE MK PZ JM NGL GMC JG HKAM WRM. Wrote the paper: AN KSL BVH HKAM WRM.