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Research Article

Pharmacogenetic Analysis of Pediatric Patients with Acute Lymphoblastic Leukemia: A Possible Association between Survival Rate and ITPA Polymorphism

  • Hyery Kim,

    Affiliations: Department of Pediatrics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea, Department of Pediatrics, Seoul National University College of Medicine, SMG-SNU Boramae Medical Center, Seoul, Korea

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  • Hyoung Jin Kang mail,

    kanghj@snu.ac.kr

    Affiliation: Department of Pediatrics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea

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  • Hyo Jeong Kim,

    Affiliation: Department of Pediatrics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea

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  • Mi Kyung Jang,

    Affiliation: Department of Pediatrics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea

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  • Nam Hee Kim,

    Affiliation: Department of Pediatrics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea

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  • Yongtaek Oh,

    Affiliation: YeBT Co., LTD, Seoul, Korea

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  • Byoung-Don Han,

    Affiliation: YeBT Co., LTD, Seoul, Korea

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  • Ji-Yeob Choi,

    Affiliation: Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea

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  • Chul Woo Kim,

    Affiliation: Department of Pathology, Seoul National University College of Medicine, Seoul, Korea

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  • Ji Won Lee,

    Affiliation: Department of Pediatrics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea

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  • Kyung Duk Park,

    Affiliation: Department of Pediatrics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea

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  • Hee Young Shin,

    Affiliation: Department of Pediatrics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea

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  • Hyo Seop Ahn

    Affiliation: Department of Pediatrics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea

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  • Published: September 24, 2012
  • DOI: 10.1371/journal.pone.0045558

About the Authors

Hyery Kim, Hyoung Jin Kang, Hyo Jeong Kim, Mi Kyung Jang, Nam Hee Kim, Ji Won Lee, Kyung Duk Park, Hee Young Shin, Hyo Seop Ahn
Department of Pediatrics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
Hyery Kim
Department of Pediatrics, Seoul National University College of Medicine, SMG-SNU Boramae Medical Center, Seoul, Korea
Yongtaek Oh, Byoung-Don Han
YeBT Co., LTD, Seoul, Korea
Ji-Yeob Choi
Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea
Chul Woo Kim
Department of Pathology, Seoul National University College of Medicine, Seoul, Korea

Corresponding Author

Email: kanghj@snu.ac.kr

Competing Interests

Yongtaek Oh and Byoung-Don Han are employees of the research center in YeBT Co. Ltd. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: H.J. Kang KDP HYS HSA. Performed the experiments: HK H.J. Kim YO BDH CWK. Analyzed the data: HK H.J. Kang JWL. Wrote the paper: HK H.J. Kang. Organized collection of patients' samples and data: MKJ NHK. Performed statistical and bioinformatic analyses: JYC.