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Research Article

Humanized Mouse Model of Skin Inflammation Is Characterized by Disturbed Keratinocyte Differentiation and Influx of IL-17A Producing T Cells

  • Vivian L. de Oliveira,

    Affiliation: Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Romy R. M. C. Keijsers,

    Affiliations: Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, Dermatology Department, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Peter C. M. van de Kerkhof,

    Affiliation: Dermatology Department, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Marieke M. B. Seyger,

    Affiliation: Dermatology Department, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Esther Fasse,

    Affiliation: Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Lars Svensson,

    Affiliation: Department of Disease Pharmacology, LEO Pharma, Ballerup, Denmark

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  • Markus Latta,

    Affiliation: Department of Disease Pharmacology, LEO Pharma, Ballerup, Denmark

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  • Hanne Norsgaard,

    Affiliation: Department of Molecular Biomedicine, LEO Pharma, Ballerup, Denmark

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  • Tord Labuda,

    Affiliation: Department of Molecular Biomedicine, LEO Pharma, Ballerup, Denmark

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  • Pieter Hupkens,

    Affiliation: Department of Plastic Surgery Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Piet E. J. van Erp,

    Affiliation: Dermatology Department, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Irma Joosten,

    Affiliation: Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Hans J. P. M. Koenen mail

    h.koenen@labgk.umcn.nl

    Affiliation: Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Published: October 19, 2012
  • DOI: 10.1371/journal.pone.0045509

About the Authors

Vivian L. de Oliveira, Romy R. M. C. Keijsers, Esther Fasse, Irma Joosten, Hans J. P. M. Koenen
Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Romy R. M. C. Keijsers, Peter C. M. van de Kerkhof, Marieke M. B. Seyger, Piet E. J. van Erp
Dermatology Department, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Pieter Hupkens
Department of Plastic Surgery Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Lars Svensson, Markus Latta
Department of Disease Pharmacology, LEO Pharma, Ballerup, Denmark
Hanne Norsgaard, Tord Labuda
Department of Molecular Biomedicine, LEO Pharma, Ballerup, Denmark

Corresponding Author

Email: h.koenen@labgk.umcn.nl

Competing Interests

Svensson L, Latta M, Norsgaard H, and Labuda T are all employees at LEO Pharma A/S. This does not alter our adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: VLO IJ HJPMK. Performed the experiments: VLO HN EF RRMCK. Analyzed the data: VLO HJPMK PEvE LS MMBS. Contributed reagents/materials/analysis tools: PH PCMvdK ML TL. Wrote the paper: VLO HJPMK IJ.