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Research Article

Microarray Meta-Analysis Identifies Acute Lung Injury Biomarkers in Donor Lungs That Predict Development of Primary Graft Failure in Recipients

  • Pingzhao Hu equal contributor,

    equal contributor Contributed equally to this work with: Pingzhao Hu, Xinchen Wang

    Affiliation: The Centre for Applied Genomics, Hospital for Sick Children, Toronto, Ontario, Canada

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  • Xinchen Wang equal contributor,

    equal contributor Contributed equally to this work with: Pingzhao Hu, Xinchen Wang

    Affiliation: Keenan Research Center at the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Interdepartmental Division of Critical Care, University of Toronto, Toronto, Ontario, Canada

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  • Jack J. Haitsma,

    Affiliation: Keenan Research Center at the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Interdepartmental Division of Critical Care, University of Toronto, Toronto, Ontario, Canada

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  • Suleiman Furmli,

    Affiliation: Keenan Research Center at the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Interdepartmental Division of Critical Care, University of Toronto, Toronto, Ontario, Canada

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  • Hussain Masoom,

    Affiliation: Keenan Research Center at the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Interdepartmental Division of Critical Care, University of Toronto, Toronto, Ontario, Canada

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  • Mingyao Liu,

    Affiliation: Thoracic Surgery Research Laboratory, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada

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  • Yumiko Imai,

    Affiliation: Biological Informatics and Experimental Therapeutics Akita University Graduate School of Medicine, Akita City, Akita, Japan

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  • Arthur S. Slutsky,

    Affiliation: Keenan Research Center at the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Interdepartmental Division of Critical Care, University of Toronto, Toronto, Ontario, Canada

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  • Joseph Beyene,

    Affiliation: Program in Population Genomics, Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada

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  • Celia M. T. Greenwood,

    Affiliation: Centre for Clinical Epidemiology, Lady Davis Institute and Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada

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  • Claudia dos Santos mail

    dossantosc@smh.toronto.on.ca

    Affiliation: Keenan Research Center at the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Interdepartmental Division of Critical Care, University of Toronto, Toronto, Ontario, Canada

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  • Published: October 12, 2012
  • DOI: 10.1371/journal.pone.0045506

About the Authors

Pingzhao Hu
The Centre for Applied Genomics, Hospital for Sick Children, Toronto, Ontario, Canada
Xinchen Wang, Jack J. Haitsma, Suleiman Furmli, Hussain Masoom, Arthur S. Slutsky, Claudia dos Santos
Keenan Research Center at the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Interdepartmental Division of Critical Care, University of Toronto, Toronto, Ontario, Canada
Mingyao Liu
Thoracic Surgery Research Laboratory, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
Yumiko Imai
Biological Informatics and Experimental Therapeutics Akita University Graduate School of Medicine, Akita City, Akita, Japan
Joseph Beyene
Program in Population Genomics, Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
Celia M. T. Greenwood
Centre for Clinical Epidemiology, Lady Davis Institute and Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada

Corresponding Author

Email: dossantosc@smh.toronto.on.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CdS PH XW CG JB. Performed the experiments: PH XW JH SF YI HM. Analyzed the data: CdS PH YI XW JH. Contributed reagents/materials/analysis tools: CdC JH PH ASS ML. Wrote the paper: PH XW CdS.