Advertisement
Research Article

The Genomic Landscape of TP53 and p53 Annotated High Grade Ovarian Serous Carcinomas from a Defined Founder Population Associated with Patient Outcome

  • Paulina M. Wojnarowicz,

    Affiliation: Department of Human Genetics, McGill University, Montreal, Quebec, Canada

    X
  • Kathleen Klein Oros,

    Affiliation: Division of Clinical Epidemiology and Segal Cancer Centre, Lady Davis Research Institute, Jewish General Hospital, Montreal, Quebec, Canada

    X
  • Michael C. J. Quinn,

    Affiliation: Centre de recherche du Centre hospitalier de l’Université de Montréal (CRCHUM), Institut du Cancer de Montréal, Montreal, Quebec, Canada

    X
  • Suzanna L. Arcand,

    Affiliation: The Research Institute of the McGill University Health Centre (MUHC), Montreal, Quebec, Canada

    X
  • Karen Gambaro,

    Affiliation: Department of Human Genetics, McGill University, Montreal, Quebec, Canada

    X
  • Jason Madore,

    Affiliation: Centre de recherche du Centre hospitalier de l’Université de Montréal (CRCHUM), Institut du Cancer de Montréal, Montreal, Quebec, Canada

    X
  • Ashley H. Birch,

    Affiliation: Department of Human Genetics, McGill University, Montreal, Quebec, Canada

    X
  • Manon de Ladurantaye,

    Affiliation: Centre de recherche du Centre hospitalier de l’Université de Montréal (CRCHUM), Institut du Cancer de Montréal, Montreal, Quebec, Canada

    X
  • Kurosh Rahimi,

    Affiliation: Department of Pathology, Centre Hospitalier de l’Université de Montréal (CHUM), Montreal, Quebec, Canada

    X
  • Diane M. Provencher,

    Affiliations: Centre de recherche du Centre hospitalier de l’Université de Montréal (CRCHUM), Institut du Cancer de Montréal, Montreal, Quebec, Canada, Division of Gynecologic Oncology, Université de Montréal, Montreal, Quebec, Canada

    X
  • Anne-Marie Mes-Masson,

    Affiliations: Centre de recherche du Centre hospitalier de l’Université de Montréal (CRCHUM), Institut du Cancer de Montréal, Montreal, Quebec, Canada, Department of Medicine, Université de Montréal, Montreal, Quebec, Canada

    X
  • Celia M. T. Greenwood,

    Affiliations: Division of Clinical Epidemiology and Segal Cancer Centre, Lady Davis Research Institute, Jewish General Hospital, Montreal, Quebec, Canada, Department of Oncology, McGill University, Montreal, Quebec, Canada, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada

    X
  • Patricia N. Tonin mail

    patricia.tonin@mcgill.ca

    Affiliations: Department of Human Genetics, McGill University, Montreal, Quebec, Canada, The Research Institute of the McGill University Health Centre (MUHC), Montreal, Quebec, Canada, Department of Medicine, McGill University, Montreal, Quebec, Canada

    X
  • Published: September 20, 2012
  • DOI: 10.1371/journal.pone.0045484

About the Authors

Paulina M. Wojnarowicz, Karen Gambaro, Ashley H. Birch, Patricia N. Tonin
Department of Human Genetics, McGill University, Montreal, Quebec, Canada
Kathleen Klein Oros, Celia M. T. Greenwood
Division of Clinical Epidemiology and Segal Cancer Centre, Lady Davis Research Institute, Jewish General Hospital, Montreal, Quebec, Canada
Michael C. J. Quinn, Jason Madore, Manon de Ladurantaye, Diane M. Provencher, Anne-Marie Mes-Masson
Centre de recherche du Centre hospitalier de l’Université de Montréal (CRCHUM), Institut du Cancer de Montréal, Montreal, Quebec, Canada
Suzanna L. Arcand, Patricia N. Tonin
The Research Institute of the McGill University Health Centre (MUHC), Montreal, Quebec, Canada
Kurosh Rahimi
Department of Pathology, Centre Hospitalier de l’Université de Montréal (CHUM), Montreal, Quebec, Canada
Diane M. Provencher
Division of Gynecologic Oncology, Université de Montréal, Montreal, Quebec, Canada
Anne-Marie Mes-Masson
Department of Medicine, Université de Montréal, Montreal, Quebec, Canada
Celia M. T. Greenwood
Department of Oncology, McGill University, Montreal, Quebec, Canada
Celia M. T. Greenwood
Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada
Patricia N. Tonin
Department of Medicine, McGill University, Montreal, Quebec, Canada

Corresponding Author

Email: patricia.tonin@mcgill.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PNT A-MM-M CMTG. Performed the experiments: PMW KKO MCJQ SLA KG JM AHB CMTG PNT. Analyzed the data: PMW KKO MCJQ SLA KG JM AHB CMTG PNT. Contributed reagents/materials/analysis tools: KKO CMTG SLA MdL DMP A-MM-M JM PNT. Wrote the paper: PNT PMW. Blinded review of pathology specimens: KR.