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Research Article

Melanoma-Associated Cancer-Testis Antigen 16 (CT16) Regulates the Expression of Apoptotic and Antiapoptotic Genes and Promotes Cell Survival

  • Camilla Nylund,

    Affiliation: Department of Biochemistry and Food Chemistry, University of Turku, Turku, Finland

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  • Pekka Rappu mail,

    pekka.rappu@utu.fi

    Affiliation: Department of Biochemistry and Food Chemistry, University of Turku, Turku, Finland

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  • Eveliina Pakula,

    Affiliation: Department of Biochemistry and Food Chemistry, University of Turku, Turku, Finland

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  • Aleksi Heino,

    Affiliation: Department of Biochemistry and Food Chemistry, University of Turku, Turku, Finland

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  • Laura Laato,

    Affiliation: Department of Biochemistry and Food Chemistry, University of Turku, Turku, Finland

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  • Laura L. Elo,

    Affiliation: Department of Mathematics, University of Turku, Turku, Finland

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  • Pia Vihinen,

    Affiliation: Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland

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  • Seppo Pyrhönen,

    Affiliation: Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland

    X
  • Gethin R. Owen,

    Affiliation: Department of Oral, Biological and Medical Sciences, University of British Columbia, Vancouver, British Columbia, Canada

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  • Hannu Larjava,

    Affiliation: Department of Oral, Biological and Medical Sciences, University of British Columbia, Vancouver, British Columbia, Canada

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  • Markku Kallajoki,

    Affiliation: Department of Pathology, University of Turku, Turku, Finland

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  • Jyrki Heino

    Affiliation: Department of Biochemistry and Food Chemistry, University of Turku, Turku, Finland

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  • Published: September 21, 2012
  • DOI: 10.1371/journal.pone.0045382

About the Authors

Camilla Nylund, Pekka Rappu, Eveliina Pakula, Aleksi Heino, Laura Laato, Jyrki Heino
Department of Biochemistry and Food Chemistry, University of Turku, Turku, Finland
Laura L. Elo
Department of Mathematics, University of Turku, Turku, Finland
Pia Vihinen, Seppo Pyrhönen
Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
Gethin R. Owen, Hannu Larjava
Department of Oral, Biological and Medical Sciences, University of British Columbia, Vancouver, British Columbia, Canada
Markku Kallajoki
Department of Pathology, University of Turku, Turku, Finland

Corresponding Author

Email: pekka.rappu@utu.fi

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HL MK JH. Performed the experiments: CN PR EP AH LL GRO . Analyzed the data: CN PR LLE MK. Contributed reagents/materials/analysis tools: PV SP MK. Wrote the paper: CN PR JH.