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Research Article

Violacein Induces Death of Resistant Leukaemia Cells via Kinome Reprogramming, Endoplasmic Reticulum Stress and Golgi Apparatus Collapse

  • Karla C. S. Queiroz,

    Affiliations: Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Department of Biochemistry, Institute of Biology, University of Campinas, Brazil (UNICAMP), Campinas, São Paulo, Brazil

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  • Renato Milani,

    Affiliation: Department of Biochemistry, Institute of Biology, University of Campinas, Brazil (UNICAMP), Campinas, São Paulo, Brazil

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  • Roberta R. Ruela-de-Sousa,

    Affiliations: Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Department of Biochemistry, Institute of Biology, University of Campinas, Brazil (UNICAMP), Campinas, São Paulo, Brazil

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  • Gwenny M. Fuhler,

    Affiliation: Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands

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  • Giselle Z. Justo,

    Affiliation: Department of Cell Biology and Department of Biochemistry, Federal University of São Paulo (UNIFESP), São Paulo, São Paulo, Brazil

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  • Willian F. Zambuzzi,

    Affiliations: Multidisciplinary Lab in Dental Research, Heath Sciences School, University of Grande Rio (UNIGRANRIO), Rio de Janeiro, Brazil, Biotechnology Lab, Bioengineering Sector, National Institute of Metrology, Quality and Technology (Inmetro), Duque de Caxias, Rio de Janeiro, Brazil

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  • Nelson Duran,

    Affiliation: Biological Chemistry Laboratory, Institute of Chemistry, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil

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  • Sander H. Diks,

    Affiliation: Beatrix Children's Hospital, Department of Pediatric Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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  • C. Arnold Spek,

    Affiliation: Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Carmen V. Ferreira,

    Affiliation: Department of Biochemistry, Institute of Biology, University of Campinas, Brazil (UNICAMP), Campinas, São Paulo, Brazil

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  • Maikel P. Peppelenbosch mail

    M.Peppelenbosch@erasmusmc.nl

    Affiliation: Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands

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  • Published: October 11, 2012
  • DOI: 10.1371/journal.pone.0045362

About the Authors

Karla C. S. Queiroz, Roberta R. Ruela-de-Sousa, C. Arnold Spek
Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Karla C. S. Queiroz, Renato Milani, Roberta R. Ruela-de-Sousa, Carmen V. Ferreira
Department of Biochemistry, Institute of Biology, University of Campinas, Brazil (UNICAMP), Campinas, São Paulo, Brazil
Gwenny M. Fuhler, Maikel P. Peppelenbosch
Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands
Giselle Z. Justo
Department of Cell Biology and Department of Biochemistry, Federal University of São Paulo (UNIFESP), São Paulo, São Paulo, Brazil
Willian F. Zambuzzi
Multidisciplinary Lab in Dental Research, Heath Sciences School, University of Grande Rio (UNIGRANRIO), Rio de Janeiro, Brazil
Willian F. Zambuzzi
Biotechnology Lab, Bioengineering Sector, National Institute of Metrology, Quality and Technology (Inmetro), Duque de Caxias, Rio de Janeiro, Brazil
Nelson Duran
Biological Chemistry Laboratory, Institute of Chemistry, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
Sander H. Diks
Beatrix Children's Hospital, Department of Pediatric Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

Corresponding Author

Email: M.Peppelenbosch@erasmusmc.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CVF MPP KCSQ. Performed the experiments: KCSQ RRRS GMF GZJ WFZ SHD CVF. Analyzed the data: KCSQ RM CVF MPP. Contributed reagents/materials/analysis tools: CAS ND. Wrote the paper: MPP KCSQ CVF.