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Research Article

A Pilot Study to Examine the Effect of Chronic Treatment with Immunosuppressive Drugs on Mucociliary Clearance in a Vagotomized Murine Model

  • Abhiram R. Bhashyam,

    Affiliation: Department of Biomedical Engineering, The Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Peter J. Mogayzel Jr.,

    Affiliation: Department of Pediatrics, The Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Sharon McGrath-Morrow,

    Affiliation: Department of Pediatrics, The Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Enid Neptune,

    Affiliation: Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Alla Malinina,

    Affiliation: Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • James Fox,

    Affiliation: Department of Radiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Beth L. Laube mail

    blaube@jhmi.edu

    Affiliation: Department of Pediatrics, The Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Published: September 20, 2012
  • DOI: 10.1371/journal.pone.0045312

About the Authors

Peter J. Mogayzel Jr., Sharon McGrath-Morrow, Beth L. Laube
Department of Pediatrics, The Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America
Abhiram R. Bhashyam
Department of Biomedical Engineering, The Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America
Enid Neptune, Alla Malinina
Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America
James Fox
Department of Radiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

Corresponding Author

Email: blaube@jhmi.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BL AB PM SM. Performed the experiments: BL AB SM AM. Analyzed the data: BL AB SM AM EN. Contributed reagents/materials/analysis tools: PM SM EN. Wrote the paper: BL AB SM PM. Assisted with image acquisition: JF. Assisted with data collection: JF.