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Research Article

Viscoelastic Properties of Differentiating Blood Cells Are Fate- and Function-Dependent

  • Andrew E. Ekpenyong,

    Affiliation: Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge, United Kingdom

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  • Graeme Whyte,

    Affiliation: Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge, United Kingdom

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  • Kevin Chalut,

    Affiliation: Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge, United Kingdom

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  • Stefano Pagliara,

    Affiliation: Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge, United Kingdom

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  • Franziska Lautenschläger,

    Affiliation: Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge, United Kingdom

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  • Christine Fiddler,

    Affiliation: Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's and Papworth Hospitals, Cambridge, United Kingdom

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  • Stephan Paschke,

    Affiliation: Department of Surgery, University of Ulm, Ulm, Germany

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  • Ulrich F. Keyser,

    Affiliation: Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge, United Kingdom

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  • Edwin R. Chilvers,

    Affiliation: Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's and Papworth Hospitals, Cambridge, United Kingdom

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  • Jochen Guck mail

    jochen.guck@biotec.tu-dresden.de

    Affiliations: Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge, United Kingdom, Biotechnology Center, Technische Universität Dresden, Dresden, Germany

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  • Published: September 27, 2012
  • DOI: 10.1371/journal.pone.0045237

About the Authors

Andrew E. Ekpenyong, Graeme Whyte, Kevin Chalut, Stefano Pagliara, Franziska Lautenschläger, Ulrich F. Keyser, Jochen Guck
Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge, United Kingdom
Christine Fiddler, Edwin R. Chilvers
Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's and Papworth Hospitals, Cambridge, United Kingdom
Stephan Paschke
Department of Surgery, University of Ulm, Ulm, Germany
Jochen Guck
Biotechnology Center, Technische Universität Dresden, Dresden, Germany

Corresponding Author

Email: jochen.guck@biotec.tu-dresden.de

Competing Interests

Jochen Guck holds the following patents on the optical stretcher technology as pertinent to this publication: “Optical Stretcher” U.S. (#6,067,859), EU (#1,059,871), Canada (#2,322,212), Japan (#4,456,270), Hong Kong (#1,032,726). At present, the patents are not licensed to any commercial entity and no financial gains through royalties, consultancy, employment or otherwise are derived from them. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AEE FL UFK ERC JG. Performed the experiments: AEE GW KC SP FL CF. Analyzed the data: AEE GW KC SP. Contributed reagents/materials/analysis tools: AEE GW KC SP CF UFK ERC JG. Wrote the paper: AEE GW JG.