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Research Article

Loss of Expression and Function of SOCS3 Is an Early Event in HNSCC: Altered Subcellular Localization as a Possible Mechanism Involved in Proliferation, Migration and Invasion

  • Carlos Rossa Jr. mail,

    crossajr@foar.unesp.br

    Affiliation: Department of Diagnosis and Surgery-School of Dentistry at Araraquara-Universidade Estadual Paulista (UNESP), Araraquara, São Paulo, Brazil

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  • Gunhild Sommer,

    Affiliation: Department of Biochemistry and Molecular Biology, Medical University of South Carolina (MUSC), Charleston, South Carolina, United States of America

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  • Luis C. Spolidorio,

    Affiliation: Department of Physiology and Pathology-School of Dentistry at Araraquara-Universidade Estadual Paulista (UNESP), Araraquara, São Paulo, Brazil

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  • Steven A. Rosenzweig,

    Affiliation: Department of Pharmacology, Medical University of South Carolina (MUSC), Charleston, South Carolina, United States of America

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  • Dennis K. Watson,

    Affiliations: Department of Biochemistry and Molecular Biology, Medical University of South Carolina (MUSC), Charleston, South Carolina, United States of America, Department of Pathology and Laboratory Medicine, Medical University of South Carolina (MUSC), Charleston, South Carolina, United States of America

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  • Keith L. Kirkwood

    Affiliation: Department of Craniofacial Biology and Center for Oral Health, Medical University of South Carolina (MUSC), Charleston, South Carolina, United States of America

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  • Published: September 18, 2012
  • DOI: 10.1371/journal.pone.0045197

About the Authors

Carlos Rossa Jr.
Department of Diagnosis and Surgery-School of Dentistry at Araraquara-Universidade Estadual Paulista (UNESP), Araraquara, São Paulo, Brazil
Gunhild Sommer, Dennis K. Watson
Department of Biochemistry and Molecular Biology, Medical University of South Carolina (MUSC), Charleston, South Carolina, United States of America
Luis C. Spolidorio
Department of Physiology and Pathology-School of Dentistry at Araraquara-Universidade Estadual Paulista (UNESP), Araraquara, São Paulo, Brazil
Steven A. Rosenzweig
Department of Pharmacology, Medical University of South Carolina (MUSC), Charleston, South Carolina, United States of America
Dennis K. Watson
Department of Pathology and Laboratory Medicine, Medical University of South Carolina (MUSC), Charleston, South Carolina, United States of America
Keith L. Kirkwood
Department of Craniofacial Biology and Center for Oral Health, Medical University of South Carolina (MUSC), Charleston, South Carolina, United States of America

Corresponding Author

Email: crossajr@foar.unesp.br

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CRJ DKW KLK SAR. Performed the experiments: CRJ GS. Analyzed the data: CRJ LCS DKW SAR. Contributed reagents/materials/analysis tools: GS LCS. Wrote the paper: CRJ DKW SAR KLK GS.