About the Authors

Peggy Benisch

Affiliation Orthopedic Center for Musculoskeletal Research, University of Wuerzburg, Wuerzburg, Germany

Tatjana Schilling

Affiliation Orthopedic Center for Musculoskeletal Research, University of Wuerzburg, Wuerzburg, Germany

Ludger Klein-Hitpass

Affiliation Institute of Cell Biology (Tumor Research), University Hospital Essen, Essen, Germany

Sönke P. Frey

Affiliation Department of Trauma, Hand-, Plastic- and Reconstructive Surgery, University Hospital of Wuerzburg, Wuerzburg, Germany

Lothar Seefried

Affiliation Orthopedic Center for Musculoskeletal Research, University of Wuerzburg, Wuerzburg, Germany

Nadja Raaijmakers

Affiliation Orthopedic Center for Musculoskeletal Research, University of Wuerzburg, Wuerzburg, Germany

Melanie Krug

Affiliation Orthopedic Center for Musculoskeletal Research, University of Wuerzburg, Wuerzburg, Germany

Martina Regensburger

Affiliation Orthopedic Center for Musculoskeletal Research, University of Wuerzburg, Wuerzburg, Germany

Sabine Zeck

Affiliation Orthopedic Center for Musculoskeletal Research, University of Wuerzburg, Wuerzburg, Germany

Thorsten Schinke

Affiliation Department of Osteology and Biomechanics, University Medical Center Hamburg Eppendorf, Hamburg, Germany

Michael Amling

Affiliation Department of Osteology and Biomechanics, University Medical Center Hamburg Eppendorf, Hamburg, Germany

Regina Ebert

Affiliation Orthopedic Center for Musculoskeletal Research, University of Wuerzburg, Wuerzburg, Germany

Franz Jakob

f-jakob.klh@uni-wuerzburg.de

Affiliation Orthopedic Center for Musculoskeletal Research, University of Wuerzburg, Wuerzburg, Germany

Competing Interests

The authors have read the journal's policy and have the following conflicts: F. Jakob has received honoraria and travel grants for lectures, advice and expert testimony from Lilly, Amgen, Novartis, Merck Sharp and Dohme (MSD), Nycomed, Servier, Medtronic and Roche. He has received unrestricted research grants from Novartis and is involved in clinical studies related to osteoporosis drugs initiated by Lilly, Amgen, Servier and Novartis. L. Seefried has received honoraria and travel grants for lectures from Lilly, Amgen and Novartis. He is involved in clinical studies related to osteoporosis drugs initiated by Amgen, Servier and Novartis. R. Ebert received honoraria and travel grants for lectures from Lilly and Novartis. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: PB FJ. Performed the experiments: MK MR SZ LKH. Analyzed the data: LKH PB RE. Contributed reagents/materials/analysis tools: T. Schilling SPF LS NR. Wrote the paper: PB. Critical revision/substantial impulses: MA T. Schinke T. Schilling.