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Research Article

Mitochondrial Genomic Analysis of Late Onset Alzheimer’s Disease Reveals Protective Haplogroups H6A1A/H6A1B: The Cache County Study on Memory in Aging

  • Perry G. Ridge,

    Affiliations: Department of Biology, Brigham Young University, Provo, Utah, United States of America, ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, Utah, United States of America

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  • Taylor J. Maxwell,

    Affiliation: Human Genetics Center, University of Texas School of Public Health, Houston, Texas, United States of America

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  • Christopher D. Corcoran,

    Affiliations: Department of Mathematics and Statistics, Utah State University, Logan, Utah, United States of America, Center for Epidemiologic Studies, Utah State University, Logan, Utah, United States of America

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  • Maria C. Norton,

    Affiliations: Center for Epidemiologic Studies, Utah State University, Logan, Utah, United States of America, Department of Family Consumer and Human Development, Utah State University, Logan, Utah, United States of America, Department of Psychology, Utah State University, Logan, Utah, United States of America

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  • JoAnn T. Tschanz,

    Affiliations: Center for Epidemiologic Studies, Utah State University, Logan, Utah, United States of America, Department of Psychology, Utah State University, Logan, Utah, United States of America

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  • Elizabeth O’Brien,

    Affiliation: Department of Epidemiology and Population Health, University of Louisville, Louisville, Kentucky, United States of America

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  • Richard A. Kerber,

    Affiliation: Department of Epidemiology and Population Health, University of Louisville, Louisville, Kentucky, United States of America

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  • Richard M. Cawthon,

    Affiliation: Department of Human Genetics, University of Utah, Salt Lake City, Utah, United States of America

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  • Ronald G. Munger,

    Affiliations: Center for Epidemiologic Studies, Utah State University, Logan, Utah, United States of America, Department of Nutrition, Dietetics, and Food Sciences, Utah State University, Logan, Utah, United States of America

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  • John S. K. Kauwe mail

    kauwe@byu.edu

    Affiliation: Department of Biology, Brigham Young University, Provo, Utah, United States of America

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  • Published: September 17, 2012
  • DOI: 10.1371/journal.pone.0045134

About the Authors

Perry G. Ridge, John S. K. Kauwe
Department of Biology, Brigham Young University, Provo, Utah, United States of America
Perry G. Ridge
ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, Utah, United States of America
Taylor J. Maxwell
Human Genetics Center, University of Texas School of Public Health, Houston, Texas, United States of America
Christopher D. Corcoran
Department of Mathematics and Statistics, Utah State University, Logan, Utah, United States of America
Christopher D. Corcoran, Maria C. Norton, JoAnn T. Tschanz, Ronald G. Munger
Center for Epidemiologic Studies, Utah State University, Logan, Utah, United States of America
Maria C. Norton
Department of Family Consumer and Human Development, Utah State University, Logan, Utah, United States of America
Maria C. Norton, JoAnn T. Tschanz
Department of Psychology, Utah State University, Logan, Utah, United States of America
Elizabeth O’Brien, Richard A. Kerber
Department of Epidemiology and Population Health, University of Louisville, Louisville, Kentucky, United States of America
Richard M. Cawthon
Department of Human Genetics, University of Utah, Salt Lake City, Utah, United States of America
Ronald G. Munger
Department of Nutrition, Dietetics, and Food Sciences, Utah State University, Logan, Utah, United States of America

Corresponding Author

Email: kauwe@byu.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TJM EO RAK RMC JSKK. Performed the experiments: PGR TJM RMC. Analyzed the data: PGR TJM RMC JSKK. Contributed reagents/materials/analysis tools: PGR TJM CDC MCN JTT RMC RGM JSKK. Wrote the paper: PGR TJM JSKK.