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Research Article

Towards the Improved Discovery and Design of Functional Peptides: Common Features of Diverse Classes Permit Generalized Prediction of Bioactivity

  • Catherine Mooney,

    Affiliations: Complex and Adaptive Systems Laboratory, University College Dublin, Belfield, Dublin, Ireland, Conway Institute of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin, Ireland, School of Medicine and Medical Science, University College Dublin, Belfield, Dublin, Ireland

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  • Niall J. Haslam,

    Affiliations: Complex and Adaptive Systems Laboratory, University College Dublin, Belfield, Dublin, Ireland, Conway Institute of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin, Ireland, School of Medicine and Medical Science, University College Dublin, Belfield, Dublin, Ireland

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  • Gianluca Pollastri,

    Affiliations: Complex and Adaptive Systems Laboratory, University College Dublin, Belfield, Dublin, Ireland, School of Computer Science and Informatics, University College Dublin, Belfield, Dublin, Ireland

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  • Denis C. Shields mail

    denis.shields@ucd.ie

    Affiliations: Complex and Adaptive Systems Laboratory, University College Dublin, Belfield, Dublin, Ireland, Conway Institute of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin, Ireland, School of Medicine and Medical Science, University College Dublin, Belfield, Dublin, Ireland

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  • Published: October 08, 2012
  • DOI: 10.1371/journal.pone.0045012

About the Authors

Catherine Mooney, Niall J. Haslam, Gianluca Pollastri, Denis C. Shields
Complex and Adaptive Systems Laboratory, University College Dublin, Belfield, Dublin, Ireland
Catherine Mooney, Niall J. Haslam, Denis C. Shields
Conway Institute of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin, Ireland
Catherine Mooney, Niall J. Haslam, Denis C. Shields
School of Medicine and Medical Science, University College Dublin, Belfield, Dublin, Ireland
Gianluca Pollastri
School of Computer Science and Informatics, University College Dublin, Belfield, Dublin, Ireland

Corresponding Author

Email: denis.shields@ucd.ie

Competing Interests

NJH is a PLOS ONE editorial Board member. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: CM GP DCS. Performed the experiments: CM. Analyzed the data: CM DCS. Wrote the paper: CM GP DCS. Implemented webserver: CM NJH.