Towards the Improved Discovery and Design of Functional Peptides: Common Features of Diverse Classes Permit Generalized Prediction of Bioactivity

Catherine Mooney; Niall J. Haslam; Gianluca Pollastri; Denis C. Shields

doi:10.1371/journal.pone.0045012

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Peer-reviewed

Research Article

Towards the Improved Discovery and Design of Functional Peptides: Common Features of Diverse Classes Permit Generalized Prediction of Bioactivity

Catherine Mooney,

Affiliations Complex and Adaptive Systems Laboratory, University College Dublin, Belfield, Dublin, Ireland, Conway Institute of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin, Ireland, School of Medicine and Medical Science, University College Dublin, Belfield, Dublin, Ireland
⨯
Niall J. Haslam,

Affiliations Complex and Adaptive Systems Laboratory, University College Dublin, Belfield, Dublin, Ireland, Conway Institute of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin, Ireland, School of Medicine and Medical Science, University College Dublin, Belfield, Dublin, Ireland
⨯
Gianluca Pollastri,

Affiliations Complex and Adaptive Systems Laboratory, University College Dublin, Belfield, Dublin, Ireland, School of Computer Science and Informatics, University College Dublin, Belfield, Dublin, Ireland
⨯
Denis C. Shields

* E-mail: denis.shields@ucd.ie

Affiliations Complex and Adaptive Systems Laboratory, University College Dublin, Belfield, Dublin, Ireland, Conway Institute of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin, Ireland, School of Medicine and Medical Science, University College Dublin, Belfield, Dublin, Ireland
⨯

Towards the Improved Discovery and Design of Functional Peptides: Common Features of Diverse Classes Permit Generalized Prediction of Bioactivity

Catherine Mooney,
Niall J. Haslam,
Gianluca Pollastri,
Denis C. Shields

Published: October 8, 2012
https://doi.org/10.1371/journal.pone.0045012

About the Authors

Catherine Mooney

Affiliations Complex and Adaptive Systems Laboratory, University College Dublin, Belfield, Dublin, Ireland, Conway Institute of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin, Ireland, School of Medicine and Medical Science, University College Dublin, Belfield, Dublin, Ireland

Niall J. Haslam

Gianluca Pollastri

Affiliations Complex and Adaptive Systems Laboratory, University College Dublin, Belfield, Dublin, Ireland, School of Computer Science and Informatics, University College Dublin, Belfield, Dublin, Ireland

Denis C. Shields

* E-mail: denis.shields@ucd.ie

Competing Interests

NJH is a PLOS ONE editorial Board member. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: CM GP DCS. Performed the experiments: CM. Analyzed the data: CM DCS. Wrote the paper: CM GP DCS. Implemented webserver: CM NJH.

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Predictive toxicology
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Peptide hormones
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Cysteine
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Forecasting
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Phenylalanine
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Neural networks
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Glycine
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