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Research Article

Classification of Structural MRI Images in Alzheimer's Disease from the Perspective of Ill-Posed Problems

  • Ramon Casanova mail,

    Casanova@wakehealth.edu

    Affiliation: Department of Biostatistical Sciences, Wake Forest School of Medicine, North Carolina, United States of America

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  • Fang-Chi Hsu,

    Affiliation: Department of Biostatistical Sciences, Wake Forest School of Medicine, North Carolina, United States of America

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  • Mark A. Espeland, for the Alzheimer's Disease Neuroimaging Initiative

    Membership of the Alzheimer's Disease Neuroimaging Initiative is provided in the Acknowledgments.

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  • Published: October 10, 2012
  • DOI: 10.1371/journal.pone.0044877

About the Authors

Ramon Casanova, Fang-Chi Hsu
Department of Biostatistical Sciences, Wake Forest School of Medicine, North Carolina, United States of America

Corresponding Author

Email: Casanova@wakehealth.edu

Competing Interests

ADNI, one of the funders of this study, is partly funded through generous contributions from the following: Abbott; Amorfix Life Sciences Ltd.; AstraZeneca; Bayer HealthCare; BioClinica, Inc.; Biogen Idec Inc.; Bristol-Myers Squibb Company; Eisai Inc.; Elan Pharmaceuticals Inc.; Eli Lilly and Company; F. Hoffmann-La Roche Ltd and its affiliated company Genentech, Inc.; GE Healthcare; Innogenetics, N.V.; Janssen Alzheimer Immunotherapy Research & Development, LLC.; Johnson & Johnson Pharmaceutical Research & Development LLC.; Medpace, Inc.; Merck & Co., Inc.; Meso Scale Diagnostics, LLC.; Novartis Pharmaceuticals Corporation; Pfizer Inc.; Servier; Synarc Inc.; and Takeda Pharmaceutical Company. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors. .

Author Contributions

Conceived and designed the experiments: RC FCH MAE. Performed the experiments: RC FCH MAE. Analyzed the data: RC FCH MAE. Wrote the paper: RC FCH MAE.